Evidence map›Paper›PMID 35131679›Full record

ArticlePublic health2022

Impact of SARS-CoV-2 Alpha variant (B.1.1.7) on prisons, England.

Amoolya Vusirikala, Joe Flannagan, Maciej Czachorowski, Asad Zaidi, Kate A Twohig, Emma Plugge, Nicholas Ellaby, Wendy Rice, Gavin Dabrera, Dimple Y Chudasama and 1 more

Open access · greenAbstract read
In one paragraph

Article in Public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Amoolya VusirikalaNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK. Electronic address: feedback.c19epi@phe.gov.uk.
Joe FlannaganNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Maciej CzachorowskiNational Health and Justice Team, UK Health Security Agency, Wellington House, London SE1 8UG, UK.
Asad ZaidiNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Kate A TwohigNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Emma PluggeNational Health and Justice Team, UK Health Security Agency, Wellington House, London SE1 8UG, UK.
Nicholas EllabyNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Wendy RiceNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Gavin DabreraNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Dimple Y ChudasamaNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Theresa LamagniNational Infection Service, UK Health Security Agency, Colindale, London NW9 5EQ, UK.
Public Health England · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrisons are high-risk settings for infectious disease outbreaks because of their highly dynamic and crowded nature. During late 2020, prisons in England observed a surge in COVID-19 infection. This study describes the emergence of the Alpha variant in prisons during this period.

methodsAlpha and non-Alpha variant COVID-19 cases were identified in prisoners in England using address-matched laboratory notifications and genomic information from COG-UK.

resultsOf 14,094 COVID-19-positive prisoner cases between 1 October 2020 and 28 March 2021, 11.5% (n = 1621) had sequencing results. Of these, 1082 (66.7%) were identified as the Alpha variant. Twenty-nine (2.7%) Alpha cases required hospitalisation compared with only five (1.0%; P = 0.02) non-Alpha cases. A total of 14 outbreaks were identified with the median attack rate higher for Alpha (17.9%, interquartile range [IQR] 3.2%-32.2%; P = 0.11) than non-Alpha outbreaks (3.5%, IQR 2.0%-10.2%).

conclusionHigher attack rates and increased likelihood of hospitalisations were observed for Alpha cases compared with non-Alpha. This suggests a key contribution to the rise in cases, hospitalisations and outbreaks in prisons in the second wave. With prisons prone to COVID-19 outbreaks and the potential to act as reservoirs for variants of concern, sequencing of prison-associated cases alongside whole-institution vaccination should be prioritised.

Indexed as

COVID-19PrisonersEnglandHumansPrisonsSARS-CoV-2COVID-19EnglandOutbreaksPrisonsSevere acute respiratory syndrome coronavirus 2Whole-genome sequencing

Identifiers

PMID35131679
PMCPMC8712265
OpenAlexW4200025588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.