Evidence map›Paper›PMID 35130970›Full record

ArticleSkeletal muscle2022

Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years.

Salem Werdyani, Dawn Aitken, Zhiwei Gao, Ming Liu, Edward W Randell, Proton Rahman, Graeme Jones, Guangju Zhai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Salem WerdyaniDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Dawn AitkenMenzies Research Institute, University of Tasmania, Hobart, Australia.
Zhiwei GaoDivision of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Ming LiuDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Edward W RandellDiscipline of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Proton RahmanDiscipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Graeme JonesMenzies Research Institute, University of Tasmania, Hobart, Australia.
Guangju ZhaiDivision of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada. guangju.zhai@med.mun.ca.
Memorial University of Newfoundland · CAUniversity of Tasmania · AU

Funding

CIHR 143058CIHR 153298CIHR 175015CIHR FRN132178
6 · The paper itself

Abstract

backgroundSkeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of the synovial joints which are often affected by osteoarthritis (OA). The aim of this study was to identify the baseline metabolomic signatures for the longitudinal reduction of muscle strength over 10 years in the well-established community-based Tasmanian Older Adult Cohort (TASOAC).

methodsStudy participants were 50-79 year old individuals from the TASOAC. Hand grip, knee extension, and leg strength were measured at baseline, 2.6-, 5-, and 10-year follow-up points. Fasting serum samples were collected at 2.6-year follow-up point, and metabolomic profiling was performed using the TMIC Prime Metabolomics Profiling Assay. Generalized linear mixed effects model was used to identify metabolites that were associated with the reduction in muscle strength over 10 years after controlling for age, sex, and BMI. Significance level was defined at α=0.0004 after correction of multiple testing of 129 metabolites with Bonferroni method. Further, a genome-wide association study (GWAS) analysis was performed to explore if genetic factors account for the association between the identified metabolomic markers and the longitudinal reduction of muscle strength over 10 years.

resultsA total of 409 older adults (50% of them females) were included. The mean age was 60.93±6.50 years, and mean BMI was 27.12±4.18 kg/m

conclusionOur results demonstrated that elevated serum ADMA and uric acid at baseline were associated with age-dependent muscle strength reduction. They might be novel targets to prevent muscle strength loss over time.

Indexed as

Hand StrengthUric AcidAgedFemaleGenome-Wide Association StudyHumansMetabolomicsMiddle AgedMuscle, SkeletalMuscle StrengthUric AcidAsymmetric dimethylarginineBiomarkersHand gripKnee extensionLeg muscle strengthMetabolomicsMuscle strength reductionUric acid

Identifiers

PMID35130970
PMCPMC8819943
OpenAlexW4226035611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.