Evidence map›Paper›PMID 35130930›Full record

ArticleJournal of neuroinflammation2022

Marine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish.

Yingying Nie, Jingming Yang, Longjian Zhou, Zhiyou Yang, Jinyue Liang, Yayue Liu, Xiaoxiang Ma, Zhongji Qian, Pengzhi Hong, Allan V Kalueff and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
  6. Exploring the Anti-Alzheimer's Disease Potential ofJournal of fungi (Basel, Switzerland) · 2025
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  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Butenolide derivatives fromFrontiers in chemistry · 2022
    Article
  18. Frontiers in aging neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yingying NieCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Jingming YangCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Longjian ZhouCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Zhiyou YangCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Jinyue LiangCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Yayue LiuCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Xiaoxiang MaCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Zhongji QianCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Pengzhi HongCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Allan V KalueffCollege of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, China.
Cai SongCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China.
Yi ZhangCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Zhanjiang, 524088, China. hubeizhangyi@163.com.ORCID http://orcid.org/0000-0002-1600-7456
Guangdong Ocean University · CNUral Federal University · RU

Funding

basic research project of shenzhen science and technology innovation commission JCYJ20190813105005619Department of Education of Guangdong Province 2021ZDZX2064Guangdong Science and Technology Department 2021A50114marine economy promotion fund of guangdong province [2019]015natural science foundation of guangdong province 2018A030307046shenzhen dapeng new district industrial development fund PT201901-05shenzhen dapeng new district scientific and technological research and development fund KJYF202001-07the innovation and development project about marine economy demostration of zhanjiang city XM-202008-01B1the national natural science foundation 21807015yangfan talent project of guangdong province 201433009
6 · The paper itself

Abstract

backgroundMounting evidences indicate that oxidative stress, neuroinflammation, and dysregulation of gut microbiota are related to neurodegenerative disorders (NDs). Butyrolactone I (BTL-I), a marine fungal metabolite, was previously reported as an in vitro neuroprotectant and inflammation inhibitor. However, little is known regarding its in vivo effects, whereas zebrafish (Danio rerio) could be used as a convenient in vivo model of toxicology and central nervous system (CNS) diseases.

methodsHere, we employed in vivo and in silico methods to investigate the anti-NDs potential of BTL-I. Specifically, we established a cognitive deficit model in zebrafish by intraperitoneal (i.p.) injection of aluminum trichloride (AlCl

resultsBTL-I dose-dependently ameliorated AlCl

conclusionsThe present findings suggest that BTL-I is a potential therapeutic agent for preventing CNS deficits caused by inflammation, neurotoxicity, and gut flora imbalance.

Indexed as

Gastrointestinal MicrobiomeZebrafish4-ButyrolactoneAcetylcholinesteraseAluminum ChlorideAnimalsCognitionInflammationOxidative Stress4-ButyrolactoneAcetylcholinesteraseAluminum Chloridebutyrolactone IAcetylcholinesteraseButyrolactone IInflammationIntestinal floraNeurodegenerative diseasesOxidative stress

Identifiers

PMID35130930
PMCPMC8822793
OpenAlexW4210364177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.