ArticleBMC biology2022
Ionotropic receptors in the turnip moth Agrotis segetum respond to repellent medium-chain fatty acids.
Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 43 citations in OpenAlex.
- Functional conservation of IR75q.2 in the recognition of volatile acids and aldehydes in two Spodoptera species.Crop health · 2026Article
- Noses on the wing: the olfactory capacity of hawkmoth wings.The Journal of experimental biology · 2026Article
- IR25a-like Receptors are Required for Olfactory Detection of Plant Volatiles in the Carmine Spider Mite.Journal of chemical ecology · 2026Article
- Hawkmoths can smell with grooming organs on their legs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Identification of candidate chemosensory receptors based on transcriptome analysis in the monophagous insect Protegira songi (Lepidoptera, Noctuidae).BMC genomics · 2026Article
- Genome-Wide Characterization of Four Gastropod Species Ionotropic Receptors Reveals Diet-Linked Evolutionary Patterns of Functional Divergence.Animals : an open access journal from MDPI · 2026Article
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- Alternative strategies based on transgenic Drosophila melanogaster for the functional characterization of insect Ionotropic Receptors.Biological research · 2025Article
- Genome-Wide Identification and Evolutionary Analysis ofAnimals : an open access journal from MDPI · 2025Article
- The conserved IR75 subfamily mediates carboxylic acid detection in insects of public health and agricultural importance.Journal of insect science (Online) · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families.BMC biology · 2025Article
- CRISPR/Cas9-Based Genome Editing of Fall Armyworm (Biomolecules · 2024Review
- Few chemoreceptor genes in the ambrosia beetle Trypodendron lineatum may reflect its specialized ecology.BMC genomics · 2024Article
- Females smell differently: characteristics and significance of the most common olfactory sensilla of female silkmoths.Proceedings. Biological sciences · 2024Article
- Perception, regulation, and effects on longevity of pollen fatty acids in the honey bee, Apis mellifera.PloS one · 2024Article
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- Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors.PLoS neglected tropical diseases · 2023Article
- Characterization of Ionotropic Receptor GenePlants (Basel, Switzerland) · 2023Article
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn insects, airborne chemical signals are mainly detected by two receptor families, odorant receptors (ORs) and ionotropic receptors (IRs). Functions of ORs have been intensively investigated in Diptera and Lepidoptera, while the functions and evolution of the more ancient IR family remain largely unexplored beyond Diptera.
resultsHere, we identified a repertoire of 26 IRs from transcriptomes of female and male antennae, and ovipositors in the moth Agrotis segetum. We observed that a large clade formed by IR75p and IR75q expansions is closely related to the acid-sensing IRs identified in Diptera. We functionally assayed each of the five AsegIRs from this clade using Xenopus oocytes and found that two receptors responded to the tested ligands. AsegIR75p.1 responded to several compounds but hexanoic acid was revealed to be the primary ligand, and AsegIR75q.1 responded primarily to octanoic acid, and less so to nonanoic acid. It has been reported that the C
conclusionsOur results significantly expand the current knowledge of the insect IR family. Based on the functional data in combination with phylogenetic analysis, we propose that subfunctionalization after gene duplication plays an important role in the evolution of ligand specificities of the acid-sensing IRs in Lepidoptera.
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