Evidence map›Paper›PMID 35130831›Full record

ArticleBMC microbiology2022

Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria.

Jun Li, Mengli Tang, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Mingxiang Zou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jun LiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Mengli TangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Fengjun XiaDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Changhang MinDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yongmei HuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Haichen WangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Mingxiang ZouDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. zoumingxiang@csu.edu.cn.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure. However, polymyxin B-heteroresistant isolates are rare in individuals living in the community. We report a polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae (hvKP) isolate from an individual in the community with asymptomatic bacteriuria.

resultsThe NYTJ35 isolate had multiple virulence genes that encoded a mucoid phenotype regulator (rmpA), aerobactin (iucABCD-iutA), salmochelin (iroBCDN), yersiniabactin (irp1-2 and ybtAEPQSTUX), and a truncated rmpA2. Infection of galleria mellonella larvae indicated the isolate was hypervirulent. Antimicrobial susceptibility testing showed it was susceptible to all tested antibiotics except polymyxin B. The proportion of surviving bacteria was 1.2 × 10

conclusionsWe identified the co-occurrence of hypervirulence and polymyxin B heteroresistance in a K. pneumoniae isolate from an individual with asymptomatic bacteriuria. We suggest the use of increased screening for hvKP in individuals living in the community.

Indexed as

AnimalsAsymptomatic InfectionsBacteriuriaDrug Resistance, Multiple, BacterialHumansKlebsiella InfectionsKlebsiella pneumoniaeLarvaMaleMicrobial Sensitivity TestsMothsPolymyxin BVirulenceVirulence FactorsWhole Genome SequencingPolymyxin BVirulence FactorsAsymptomatic bacteriuriaCommunity-dwelling adultHypervirulent K. pneumoniaePolymyxin B heteroresistanceUrine specimenWhole genome sequencing

Identifiers

PMID35130831
PMCPMC8818840
OpenAlexW4210339160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.