Evidence map›Paper›PMID 35130730›Full record

ArticlemBio2021

Nitrate Is an Environmental Cue in the Gut for Salmonella enterica Serovar Typhimurium Biofilm Dispersal through Curli Repression and Flagellum Activation via Cyclic-di-GMP Signaling.

Amanda L Miller, Lauren K Nicastro, Shingo Bessho, Kaitlyn Grando, Aaron P White, Yi Zhang, Gillian Queisser, Bettina A Buttaro, Çagla Tükel

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Gut microbes · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Biofilm · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Bacterial biofilms in the human body: prevalence and impacts on health and disease.Frontiers in cellular and infection microbiology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amanda L MillerCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Lauren K NicastroCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Shingo BesshoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Kaitlyn GrandoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Aaron P WhiteVaccine and Infectious Disease Organization-International Vaccine Centre, Saskatoon, Saskatchewan, Canada.ORCID 0000-0003-2746-5265
Yi ZhangFels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Gillian QueisserDepartment of Mathematics, College of Science and Technology, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Bettina A ButtaroThrombosis Research Center, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.
Çagla TükelCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple Universitygrid.264727.2, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7073-0226
Temple University · USTemple College · US

Funding

The role of bacterial amyloid curli in Alzheimer's DiseaseR01AI153325 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2024
$2.4M
Pathogenicity of amyloid containing biofilmsR21AI148770 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2021
$436k
Immune recognition mechanisms of bacterial biofilms in the gutR21AI151893 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2021
$436k
NIAID NIH HHS R01 AI153325NIAID NIH HHS R21 AI148770NIAID NIH HHS R21 AI151893
6 · The paper itself

Abstract

Curli, a major component of the bacterial biofilms in the intestinal tract, activates pattern recognition receptors and triggers joint inflammation after infection with Salmonella enterica serovar Typhimurium. The factors that allow

Indexed as

Salmonella entericaSalmonella typhimuriumBacterial ProteinsBiofilmsCuesCyclic GMPFlagellaGene Expression Regulation, BacterialHumansInflammationNitratesSerogroupBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPNitratesbiofilmsc-di-GMPcurlicyclic GMPflagellagut inflammationnitrateSalmonella

Identifiers

PMID35130730
PMCPMC8822344
OpenAlexW4210905815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.