Evidence map›Paper›PMID 35130718›Full record

ArticleCirculation research2022

Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD.

Mathias Hohl, Simina-Ramona Selejan, Jan Wintrich, Ulrike Lehnert, Thimoteus Speer, Clara Schneider, Muriel Mauz, Philipp Markwirth, Dickson W L Wong, Peter Boor and 13 more

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Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Pleiotropic effects of renal denervation beyond blood pressure reduction.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  2. Article
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  4. Article
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  7. Mechanisms underlying atrial fibrillation in chronic kidney disease.Journal of molecular and cellular cardiology · 2025
    Review
  8. Article
  9. Application of stereotactic radiotherapy in the treatment of cardiovascular diseases through sympathectomy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  10. Review
  11. Exercise pressor reflex function is augmented in rats with chronic kidney disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  12. Article
  13. Article
  14. Article
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  16. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 3 countries.

Mathias HohlDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).ORCID 0000-0001-6946-9825
Simina-Ramona SelejanDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Jan WintrichDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).ORCID 0000-0001-6518-1453
Ulrike LehnertDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Thimoteus SpeerKlinik für Innere Medizin IV, Universität des Saarlandes, Homburg/Saar, Germany (T.S.).ORCID 0000-0002-2491-6393
Clara SchneiderDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Muriel MauzDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Philipp MarkwirthDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Dickson W L WongInstitut für Pathologie Universitätsklinikum Aachen, Germany (D.W.L.W., P.B., B.M.K.).ORCID 0000-0002-4798-2908
Peter BoorInstitut für Pathologie Universitätsklinikum Aachen, Germany (D.W.L.W., P.B., B.M.K.).
Andrey KazakovDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Martin MollenhauerFaculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, University of Cologne, Germany (M. Mollenhauer).
Benedikt LinzFaculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen, Denmark (B.L.).ORCID 0000-0002-7611-4130
Barbara Mara KlinkhammerInstitut für Pathologie Universitätsklinikum Aachen, Germany (D.W.L.W., P.B., B.M.K.).ORCID 0000-0002-1566-7129
Ulrich HübnerDepartment of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany (U.H.).
Christian UkenaDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).ORCID 0000-0002-9810-4662
Julia MoellmannDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Germany (J.M., M.L.).
Michael LehrkeDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Germany (J.M., M.L.).ORCID 0000-0003-2484-8068
Stefan WagenpfeilInstitut für Medizinische Biometrie, Epidemiologie und Medizinische Informatik, Saarland University, Homburg/Saar, Germany (S.W.).ORCID 0000-0002-4558-4041
Christian WernerDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Dominik LinzDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).ORCID 0000-0003-4893-0824
Felix MahfoudDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).ORCID 0000-0002-4425-549X
Michael BöhmDepartment of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).ORCID 0000-0002-2976-2514
Saarland University · DEUniversitätsklinikum Aachen · DERWTH Aachen University · DEInstitut für Medizinische Biometrie, Informatik und Epidemiologie · DEMaastricht University · NLUniversitätsklinikum des Saarlandes · DEUniversity Hospital Cologne · DEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with chronic kidney disease (CKD), atrial fibrillation (AF) is highly prevalent and represents a major risk factor for stroke and death. CKD is associated with atrial proarrhythmic remodeling and activation of the sympathetic nervous system. Whether reduction of the sympathetic nerve activity by renal denervation (RDN) inhibits AF vulnerability in CKD is unknown.

methodsLeft atrial (LA) fibrosis was analyzed in samples from patients with AF and concomitant CKD (estimated glomerular filtration rate [eGFR], <60 mL/min per 1.73 m

resultsSirius red staining demonstrated significantly increased LA fibrosis in patients with AF+CKD compared with AF without CKD or sinus rhythm. In rats, AD demonstrated LA structural changes with enhanced sympathetic innervation compared with control. In AD, LA enlargement was associated with prolonged duration of induced AF episodes, impaired LA conduction latency, and increased absolute conduction inhomogeneity. RDN treatment improved LA remodeling and reduced LA diameter compared with sham-operated AD. Furthermore, RDN decreased AF susceptibility and ameliorated LA conduction latency and absolute conduction inhomogeneity, independent of blood pressure reduction and renal function.

conclusionsIn an experimental rat model of CKD, RDN inhibited progression of atrial structural and electrophysiological remodeling. Therefore, RDN represents a potential therapeutic tool to reduce the risk of AF in CKD, independent of changes in renal function and blood pressure.

Indexed as

Atrial FibrillationAtrial RemodelingRenal Insufficiency, ChronicAnimalsDenervationFemaleFibrosisHumansKidneyMaleRatsRats, Sprague-Dawleyanimalsatrial fibrillationhumanskidney failure, chronicmalenervous systemrats

Identifiers

PMID35130718
OpenAlexW4210863266

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.