ArticleActa biochimica et biophysica Sinica2022
N6-methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes
Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Advances in RNA m6A modification research and its role in poultry economic traits.Poultry science · 2026Review
- NPoultry science · 2026Review
- The mechanism by which methylase METTL3 affects intramuscular fat deposition.Poultry science · 2026Article
- Transcriptome-Wide Analysis of N6-Methyladenosine Modification in the Liver of Geese at Different Growth Stages.Animals : an open access journal from MDPI · 2026Article
- Structural Analysis of the AlkB Family in Poultry.Animals : an open access journal from MDPI · 2025Article
- Multi-Omics Insights into Regulatory Mechanisms Underlying Differential Deposition of Intramuscular and Abdominal Fat in Chickens.Biomolecules · 2025Review
- Research Progress on the Role of M6A in Regulating Economic Traits in Livestock.International journal of molecular sciences · 2024Review
- ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on mBMC genomics · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have reported that the -methyladenosine demethylase ALKBH5 can regulate adipogenesis in humans. However, its function in birds remains unclear. In this study we aimed to explore the expression and function of the gene in chicken adipose tissue. The results showed that is widely expressed in various chicken tissues, and the expression of is relatively higher in abdominal adipose tissue. In addition, the expression of in abdominal adipose tissue of lean broilers is higher than that in fat broilers at 2 and 3 weeks of age. Moreover, the proliferation and differentiation of preadipocytes are associated with reduced and increased expression of , respectively. We also found that knockout promotes preadipocyte proliferation, as evidenced by an increase in cell viability, DNA replication activity, G-S cell cycle progression, and the expressions of and . Furthermore, after knockout of , the lipid droplet accumulation and the expression of , , and are reduced significantly. Thus, our results indicated that ALKBH5 is a novel regulator of proliferation and differentiation of chicken preadipocytes.
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