Evidence map›Paper›PMID 35130584›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2022

Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics.

Yangzhi Zhu, Shaopei Li, Jinghang Li, Natashya Falcone, Qingyu Cui, Shilp Shah, Martin C Hartel, Ning Yu, Patric Young, Natan Roberto de Barros and 12 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 106 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Photonic Nanomaterials for Wearable Health Solutions.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Recent Advances in Transparent Electrodes and Their Multimodal Sensing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 3 countries.

Yangzhi ZhuTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.ORCID https://orcid.org/0000-0003-2920-3365
Shaopei LiTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Jinghang LiTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.ORCID https://orcid.org/0000-0003-1960-9839
Natashya FalconeTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Qingyu CuiDepartment of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Shilp ShahTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Martin C HartelTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Ning YuDepartment of Chemical and Environmental Engineering, University of California-Riverside, Riverside, CA, 92521, USA.
Patric YoungTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Natan Roberto de BarrosTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Zhuohong WuDepartment of Nanoengineering, University of California-San Diego, San Diego, CA, 92093, USA.
Reihaneh HaghniazTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Menekse ErmisTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Canran WangAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
Heemin KangDepartment of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.
Junmin LeeTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Solmaz KaramikamkarTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Samad AhadianTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Vadim JucaudTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Mehmet R DokmeciTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Han-Jun KimTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.ORCID https://orcid.org/0000-0001-9238-7238
Ali KhademhosseiniTerasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.ORCID https://orcid.org/0000-0002-2692-1524
Terasaki Foundation · USUniversity of California, Los Angeles · USCalifornia Institute of Technology · USKorea University · KRPohang University of Science and Technology · KRUniversity of California, Riverside · USUniversity of San Diego · USWestlake University · CN

Funding

Engineering personalized micro-tumor ecosystemsU01CA214411 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI, SENGUPTA, SHILADITYA · 2017 to 2021
$3.5M
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.UH3TR003148 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASHAMMAKHI, NUREDDIN, MAIDMENT, NIGEL T · 2022 to 2024
$2.4M
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.UG3TR003148 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASHAMMAKHI, NUREDDIN, KHADEMHOSSEINI, ALI · 2019 to 2021
$2.1M
Oxygen generating bioinks for 3D printed bone implantsR01AR074234 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHIN, SU RYON · 2018 to 2022
$1.9M
Research Supplements to Promote DiversityR01GM126571 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOKMECI, MEHMET REMZI, YE, JING YONG · 2018 to 2021
$1.3M
NCATS NIH HHS UG3 TR003148NCATS NIH HHS UH3 TR003148NCI NIH HHS U01 CA214411NIAMS NIH HHS R01 AR074234NIGMS NIH HHS R01 GM126571NIH HHS AR074234NIH HHS CA214411NIH HHS GM126571NIH HHS TR003148
6 · The paper itself

Abstract

The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

Indexed as

Contact LensesCorneaGlucoseHumansIntraocular PressureGlucosebioelectronicsbiosensorscontact lensdiagnosticsintegrated systemspersonalized healthcaretherapeuticswearable electronics

Identifiers

PMID35130584
PMCPMC9233032
OpenAlexW4210942150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.