ArticleNature2022
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 1 pooled it
19.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 194 citations in OpenAlex.
- Revised Guidelines for Coronavirus Disease 19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients (August 2022).Transplantation and cellular therapy · 2022Guideline
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- DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants.PLoS pathogens · 2026Article
- Repurposing screens reveal a role for PKCη and NF1 in SARS-CoV-2 infection.PLoS pathogens · 2026Article
- Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Broad-acting antivirals: the pursuit of pan-viral therapeutics in the era of pandemics.Journal of virology · 2026Review
- Distinct virus-derived circular RNA molecule influences host response during SARS-CoV-2 infection.bioRxiv : the preprint server for biology · 2026Article
- Downregulation of FTO aggravates osteoarthritis with obesity by erasing mMilitary Medical Research · 2026Article
- Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature's Pragmatism.BioMed research international · 2026Review
- Proteomics and Metabolomics Profiles of Unvaccinated Nonagenarian Patients with Severe SARS-CoV-2 Infection.Journal of proteome research · 2025Article
- Comprehensive Identification and Mechanistic Evaluation of Novel DHODH Inhibitors as Potent Broad-Spectrum Antiviral Agents.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.NAR molecular medicine · 2025Article
- Chemoselective Difluoromethylation of Nucleosides.Organic letters · 2025Article
- Targeting the SARS-CoV-2 reservoir in long COVID.The Lancet. Infectious diseases · 2025Review
- Article
- Combinations of approved oral nucleoside analogues confer potent suppression of alphavirusesbioRxiv : the preprint server for biology · 2025Article
- Effectiveness and Tolerability of Dual Antiviral Therapy in Immunosuppressed Patients with Protracted SARS-CoV-2 Infection.Infectious disease reports · 2025Article
- Dihydropyrimidine-2-thione derivatives as SARS-CoV-2 main protease inhibitors: synthesis, SAR andRSC advances · 2025Article
- Inhaled Dry Powder of Antiviral Agents: A Promising Approach to Treating Respiratory Viral Pathogens.Viruses · 2025Review
- SARS-CoV-2 drug resistance and therapeutic approaches.Heliyon · 2025Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 3 institutions in 1 country.
David C SchultzDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. dschultz@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-7890-8815
Robert M Johnson *Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-1976-7688
Kasirajan Ayyanathan *Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jesse Miller *Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7990-4912
Kanupriya WhigDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9114-4365
Brinda KamaliaDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Mark DittmarDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2884-5630
Stuart WestonDepartment of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Holly L HammondDepartment of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Carly DillenDepartment of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeremy ArdanuyDepartment of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Louis TaylorDepartment of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
Jae Seung LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Minghua LiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Emily LeeNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Clarissa ShofflerMetabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9064-2378
Christopher PetucciMetabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Samuel ConstantEpithelix, Geneva, Switzerland.
Marc FerrerNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Christoph A ThaissDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8226-7718
Matthew B FriemanDepartment of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA. mfrieman@som.umaryland.edu.ORCID http://orcid.org/0000-0003-0107-0775
Sara CherryDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. cherrys@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-3956-6610
University of Pennsylvania · USUniversity of Maryland, Baltimore · USNational Institutes of Health · US
Funding
FELLOWSHIP TRAINING PROGRAM IN VACCINOLOGYT32AI007524 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1997 to 2026
$6.4MThe role of autophagy in innate anti-viral immunity in DrosophilaR01AI074951 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2007 to 2017
$4.2MThe role of pattern recognition and autophagy in innate anti-bunyaviral immunityR01AI150246 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2019 to 2023
$3.5MDefining the functional interface between the ER and flavivirusesR01AI140539 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, DIAMOND, MICHAEL S · 2018 to 2022
$3.0MDefining the role of microbiota-derived cyclic dinucleotides in priming antiviral immune defenses.R01AI152362 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2020 to 2024
$2.0MAntiviral immunity in the gut: how the intestinal epithelium and microbiota regulate infectionR01AI122749 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2016 to 2020
$2.0MCOVID-19: 3D Bioprinted Tissue Models for Respiratory VirusesZIATR000414 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI FERRER, MARC · 2020 to 2024
$1.1MElucidating the functional roles of long noncoding RNAs in Chikungunya virus infectionR21AI151882 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2020 to 2021
$446kSARS-CoV-2 and AutophagyR21AI158134 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI JACKSON, WILLIAM T · 2020 to 2020
$425kBroad Spectrum Anti-viral Compounds Targeting the SKI ComplexR21AI153480 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FRIEMAN, MATTHEW BRYAN · 2020 to 2021
$425kIntramural NIH HHS ZIA TR000414NIAID NIH HHS R01 AI074951NIAID NIH HHS R01 AI122749NIAID NIH HHS R01 AI140539NIAID NIH HHS R01 AI150246NIAID NIH HHS R01 AI152362NIAID NIH HHS R21 AI151882NIAID NIH HHS R21 AI153480NIAID NIH HHS R21 AI158134NIAID NIH HHS T32 AI007524Wellcome Trust
Abstract
The SARS-CoV-2 virus has infected more than 261 million people and has led to more than 5 million deaths in the past year and a half
Indexed as
Antiviral AgentsDrug Evaluation, PreclinicalNucleosidesPyrimidinesSARS-CoV-2Adenosine MonophosphateAlanineCell LineCOVID-19COVID-19 Drug TreatmentCytidineHumansHydroxylaminesAdenosine MonophosphateAlanineAntiviral AgentsCytidineHydroxylaminesmolnupiravirNucleosidespyrimidinePyrimidinesremdesivir
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.