Evidence map›Paper›PMID 35130452›Full record

ArticleInfection and immunity2022

The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model.

Kierra S Hardy, Amanda N Tuckey, Nicole A Housley, Joel Andrews, Mita Patel, Abu-Bakr Al-Mehdi, Robert A Barrington, Suzanne L Cassel, Fayyaz S Sutterwala, Jonathon P Audia

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Comparative phenotypic and genotypic analysis of distinctFrontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Autophagy in the normal and diseased cornea.Experimental eye research · 2022
    Review
  11. Review
  12. Modulation of the immune response by theFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kierra S HardyDepartment of Microbiology and Immunology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Amanda N TuckeyDepartment of Microbiology and Immunology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Nicole A HousleyDepartment of Microbiology and Immunology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Joel AndrewsMitchell Cancer Institute, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Mita PatelDepartment of Pharmcology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Abu-Bakr Al-MehdiDepartment of Pharmcology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Robert A BarringtonDepartment of Microbiology and Immunology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.
Suzanne L CasselWomen's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Fayyaz S SutterwalaWomen's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jonathon P AudiaDepartment of Microbiology and Immunology, University of South Alabamagrid.267153.4 College of Medicine, Mobile, Alabama, USA.ORCID 0000-0002-0022-4800
University of South Alabama · USCedars-Sinai Medical Center · USUSA Mitchell Cancer Institute · US

Funding

Caspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0M
NHLBI NIH HHS R01 HL118334
6 · The paper itself

Abstract

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the type III secretion system (T3SS) and its cognate exoenzyme effectors. The T3SS effector ExoU is phospholipase A

Indexed as

Pseudomonas aeruginosaPseudomonas InfectionsAnimalsCaspase 1InflammasomesInflammationMacrophagesMicePhospholipasesType III Secretion SystemsCaspase 1InflammasomesPhospholipasesType III Secretion Systemscaspase-1ExoTExoUmitochondriaNLRC4 inflammasomepneumoniaPseudomonas aeruginosasepsis

Identifiers

PMID35130452
PMCPMC8929383
OpenAlexW4210862506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.