ArticleThe Angle orthodontist2022
Lithium reduces orthodontically induced root resorption by suppressing cell death, hyalinization, and odontoclast formation in rats.
Article in The Angle orthodontist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Early apoptosis predicts orthodontically induced root resorption: inhibitory effects of lithium in a rat model.The Angle orthodontist · 2026Article
- Importance of the early phase of orthodontic force application in the induction of root resorption.The Angle orthodontist · 2025Article
- Lithium Chloride rescues Monensin-potentiated Wnt signaling inhibition in inflammatory bone loss in rats.Brazilian dental journal · 2025Article
- Inhibition of 12/15-lipoxygenase reduces orthodontically induced root resorption in rats.The Angle orthodontist · 2024Article
- Early-stage periodontal ligament compression predicts orthodontically induced root resorption in rats.The Angle orthodontist · 2024Article
- Exploring the Neuroprotective Effects of Lithium in Ischemic Stroke: A literature review.International journal of medical sciences · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine whether lithium suppresses orthodontically induced root resorption (OIRR) via two mechanisms (prevention of hyalinization in periodontal tissue and suppression of odontoclasts) and to investigate the changes in the periodontal tissue and alveolar bone, focusing on the appearance of cell death, hyalinization, and odontoclasts. MATERIALS AND
methodsThe maxillary first molars of 10-week-old male Wistar rats were moved mesially by a closed-coil spring for 14 days. Lithium chloride (LiCl; 0.64 mM/kg) or saline (control) was administered intraperitoneally daily. Tooth movements were measured using micro-computed tomography. Appearances of cell death, hyalinization, and odontoclasts were evaluated by histological analysis.
resultsOIRR observed on day 14 in the control group was suppressed strongly by LiCl administration. Apoptotic cells observed on day 1 in the compression area were gradually diminished on days 2 and 3 and transformed to hyalinization tissue in the control group. LiCl administration remarkably suppressed this cell death and subsequent hyalinization. Also, the appearance of odontoclasts in the compression area observed on day 7 was significantly suppressed by LiCl administration. Accordingly, these degenerative processes to OIRR were suppressed substantially by LiCl treatment.
conclusionsLithium reduces OIRR through the suppression of periodontal ligament cell death, hyalinization, and odontoclast formation.
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