ArticlePharmaceutical biology2022
Anti-inflammatory action of geniposide promotes wound healing in diabetic rats.
Article in Pharmaceutical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Topical application of phycocyanin accelerates wound healing in STZ-induced diabetic rats via activation of the Nrf2 signaling pathway.3 Biotech · 2025Article
- Identification of Exosome-Associated Biomarkers in Diabetic Foot Ulcers: A Bioinformatics Analysis and Experimental Validation.Biomedicines · 2025Article
- Dietary geniposide supplementation could enhance hepatic lipid metabolism, immunity, antioxidant capacity, and ammonia stress resistance in turbot (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Gardenia jasminoides fruit extract alleviates non-steroidal anti-inflammatory drug-induced gastropathy in rats.BMC complementary medicine and therapies · 2024Article
- Geniposide for treating atherosclerotic cardiovascular disease: a systematic review on its biological characteristics, pharmacology, pharmacokinetics, and toxicology.Chinese medicine · 2024Review
- Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Bone Marrow Mesenchymal Stem Cell-derived Exosomal microRNA-99b-5p Promotes Cell Growth of High Glucose-treated Human Umbilical Vein Endothelial Cells by Modulating THAP Domain Containing 2 Expression.Current stem cell research & therapy · 2024Article
- Network pharmacology and molecular docking approach to elucidate the mechanisms of safflower, phellodendron, scutellaria baicalensis, coptis, and gardenia in hand-foot syndrome.Frontiers in medicine · 2024Article
- Geniposide promotes wound healing of skin ulcers in diabetic rats through PI3K/Akt pathway.Heliyon · 2023Article
- A Pilot Study to Evaluate Genipin inInternational journal of molecular sciences · 2023Article
- Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review.Advances in pharmacological and pharmaceutical sciences · 2023Review
- Geniposide promotes splenic Treg differentiation to alleviate colonic inflammation and intestinal barrier injury in ulcerative colitis mice.Bioengineered · 2022Article
- Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAs a major active iridoid glycoside from
objectivesThis study explores the effect of geniposide in diabetic wound model by anti-inflammatory action. MATERIALS AND
methodsDiabetic rodent model in Wistar rats was induced by streptozotocin combined with high-fat feed. The selected rats were divided into control group, the diabetic model group and geniposide subgroups (200, 400 and 500 mg/kg), and orally administrated once daily with saline or geniposide. Wound area and histochemical indicators were measured on day 7 after continuous administration, to assess lesion retraction, inflammatory cells and fibroblasts.
resultsGeniposide notably enhanced lesion retraction by 1.06-1.84 times on day 7 after surgical onset in diabetic rats ( DISCUSSION AND
conclusionsGeniposide promoted diabetic wound healing by anti-inflammation and adjusting blood glucose. Further topical studies are required to evaluate effects on antibacterial activity and skin regeneration.
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