ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022
The health-related quality of life of children with multiple sclerosis is mediated by the health-related quality of life of their parents.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- FAMILY Matters: Parental Emotional State Mediates the Association Between Disease Burden and Child Self-Esteem in Pediatric-Onset Multiple Sclerosis.Journal of clinical psychology in medical settings · 2026Article
- The Use of Patient-Reported Outcome Measures in Developmental Age: A Complementary Tool for Pediatric Multiple Sclerosis Prognosis.Neurology and therapy · 2026Review
- Parental Experiences in Pediatric Multiple Sclerosis: Insights from Quantitative Research.Children (Basel, Switzerland) · 2024Review
- Well-being among parents of youth with multiple sclerosis: a preliminary longitudinal study.Frontiers in psychology · 2024Article
- Family health conditions and parental occupational status modify the relationship between pediatric-onset multiple sclerosis and parental health-related quality of life.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Addressing Health-Related Quality of Life Among Children With Multiple Sclerosis.International journal of MS careArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously found that children with the chronic disease multiple sclerosis (MS) reported lower health-related quality of life (HRQoL) when compared to children who experienced the transient illness termed monophasic acquired demyelinating syndromes (monoADS). Parents of children with MS also reported lower HRQoL.
objectivesWe evaluated whether parental HRQoL mediated the relationship between the diagnosis of MS and the HRQoL of affected children. To ascertain the effect of an MS diagnosis, we compared children with MS to those with monoADS.
methodsChildren were enrolled in a prospective multi-site Canadian study. Random effects models evaluated whether parental HRQoL mediated the relationship between the diagnosis of MS and the HRQoL of affected children, adjusting for child and family characteristics.
results207 parent-child dyads (65 MS; 142 monoADS) completed HRQoL questionnaires. When we modeled the child's HRQoL adjusting for covariates, but not the parent's HRQoL, the diagnosis of MS associated with lower HRQoL of the child (
conclusionsParental HRQoL mediated the relationship between the diagnosis of MS and the HRQoL of affected children, emphasizing the importance of family-centered care.
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Registered trials
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