Evidence map›Paper›PMID 35129780›Full record

ArticleMolecular and cellular biochemistry2022

MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin glycoside alters immunogenic and oncogenic profiles of breast cancer.

Mustafa Abdel-Latif, Ahmed Riad, Raghda A Soliman, Aisha M Elkhouly, Heba Nafae, Mohamed Z Gad, Amira Abdel Motaal, Rana A Youness

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 57 citations in OpenAlex.

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  16. Effect of onion (Nutrition research and practice · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Mustafa Abdel-LatifMolecular Genetics Research Team (MGRT), Biotechnology Program, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Ahmed RiadMolecular Genetics Research Team (MGRT), Biotechnology Program, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Raghda A SolimanMolecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Aisha M ElkhoulyMolecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Heba NafaeMolecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Mohamed Z GadDepartment of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Amira Abdel MotaalDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Rana A YounessMolecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt. r.youness@herts.ac.uk.ORCID http://orcid.org/0000-0001-6268-7942
German University in Cairo · EGCairo University · EGUniversity of Hertfordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC subtypes. Our research group has recently shed the light on the utility of natural compounds as effective immunotherapeutic agents. The aim of this study is to investigate the role of a methoxylated quercetin glycoside (MQG) isolated from Cleome droserifolia in harnessing TNBC progression and tuning the tumor microenvironment and natural killer cells cytotoxicity. Results showed that MQG showed the highest potency (IC

Indexed as

FemaleGlycosidesHumansMCF-7 CellsMicroRNAsRNA, Long NoncodingRNA, NeoplasmTriple Negative Breast NeoplasmsTumor Suppressor Protein p53GlycosidesMALAT1 long non-coding RNA, humanMicroRNAsMIRN146 microRNA, humanMIRN155 microRNA, humanRNA, Long NoncodingRNA, NeoplasmTP53 protein, humanTumor Suppressor Protein p53Breast cancerCleome droserifoliaMALAT-1miR-146amiR-155Natural Killer cellsTumor microenvironment

Identifiers

PMID35129780
OpenAlexW4221024547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.