Evidence map›Paper›PMID 35129757›Full record

ArticleLa Radiologia medica2022

A predictive model integrating deep and radiomics features based on gadobenate dimeglumine-enhanced MRI for postoperative early recurrence of hepatocellular carcinoma.

Wenyu Gao, Wentao Wang, Danjun Song, Chun Yang, Kai Zhu, Mengsu Zeng, Sheng-Xiang Rao, Manning Wang

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In one paragraph

Article in La Radiologia medica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  15. Insights into radiomics: a comprehensive review for beginners.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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  17. MRI Imaging Biomarkers for Prognostication of Hepatocellular Carcinoma.Journal of the Korean Society of Radiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wenyu Gao *Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Wentao Wang *Department of Radiology, Cancer Center, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai, 200032, China.
Danjun Song *Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Chun YangDepartment of Radiology, Cancer Center, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai, 200032, China.
Kai ZhuLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Mengsu ZengDepartment of Radiology, Cancer Center, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai, 200032, China.
Sheng-Xiang RaoDepartment of Radiology, Cancer Center, Shanghai Medical Imaging Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai, 200032, China. raoxray@163.com.
Manning WangDigital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. mnwang@fudan.edu.cn.
Shanghai Medical College of Fudan University · CNZhongshan Hospital · CNFudan University · CNShanghai Institute of Hematology · CN

Funding

chinese academy of sciences GJJSTD20170004national key research and development program of china 2017YFC0108804national natural science foundation of china 81227901national natural science foundation of china 81527805national natural science foundation of china 81571661the china international medical foundation Z-2014-07-2003-04the shanghai sailing program 19YF1408100
6 · The paper itself

Abstract

purposeHepatocellular carcinoma (HCC) is the most common liver cancer worldwide, and early recurrence of HCC after curative hepatic resection is indicative of poor prognoses. We aim to develop a predictive model for postoperative early recurrence of HCC based on deep and radiomics features from multi-phasic magnetic resonance imaging (MRI). MATERIALS AND

methodsA total of 472 HCC patients were included and divided into the training (n = 378) and validation (n = 94) cohorts in the retrospective study. We separately extracted radiomics features and deep features from eight phases of gadoxetic acid-enhanced MRI and utilized the least absolute shrinkage and selection operator logistic regression algorithm for feature selection and model construction. We integrated the selected two types of features into a combined model and established a radiomics model as well as a deep learning (DL) model for comparison.

resultsIn the training and validation cohorts, the combined model demonstrated better performance for stratifying patients at high risk of early recurrence (AUC of 0.911 and 0.840, accuracy of 0.779 and 0.777, sensitivity of 0.927 and 0.769, specificity 0.720 and 0.779) than the radiomics model (AUC of 0.740 and 0.780) and the DL model (AUC of 0.887 and 0.813).

conclusionThe combined model integrating deep and radiomics features from multi-phasic MRI is efficient for noninvasively stratifying patients at high risk of early HCC recurrence after resection.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansMagnetic Resonance ImagingMeglumineOrganometallic CompoundsRetrospective Studiesgadobenic acidMeglumineOrganometallic CompoundsDeep learningGadoxetic acid-enhanced MRIHepatocellular carcinomaRadiomicsReoccurrence

Identifiers

PMID35129757
OpenAlexW4210839760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.