Evidence map›Paper›PMID 35129691›Full record

ArticleMikrochimica acta2022

Portable electrochemical micro-workstation platform for simultaneous detection of multiple Alzheimer's disease biomarkers.

Yibiao Liu, Zhen Huang, Qing Xu, Lingyan Zhang, Qiong Liu, Tailin Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Superwettable Biosensor for Disease Biomarker Detection.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yibiao LiuLonggang District Central Hospital of Shenzhen, Shenzhen, China.
Zhen HuangLonggang District Central Hospital of Shenzhen, Shenzhen, China.
Qing XuSchool of Biomedical Engineering, Health Science Center, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, Guangdong, China.
Lingyan ZhangLonggang District Central Hospital of Shenzhen, Shenzhen, China.
Qiong LiuSchool of Biomedical Engineering, Health Science Center, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, Guangdong, China. liuqiong@szu.edu.cn.
Tailin XuSchool of Biomedical Engineering, Health Science Center, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, Guangdong, China. xutailin@szu.edu.cn.ORCID http://orcid.org/0000-0003-4037-2856

Funding

National Natural Science Foundation of China 21804007
6 · The paper itself

Abstract

Alzheimer's disease, as a most prevalent type of dementia, is quickly becoming one of the most expensive, lethal, and burdening diseases of this century. Though there are still no efficient therapies, early diagnosis and intervention are important directive significance to clinical works. Here, we develop a portable electrochemical micro-workstation platform consisting of an electrochemical micro-workstation and integrated electrochemical microarray for simultaneously detecting multiple AD biomarkers including Aβ40, Aβ42, T-tau, and P-tau181 in serum. The integrated electrochemical microarray is mainly used for droplet sample manipulation and signal generation. The micro-workstation can regulate signals and transfer the signals to a smartphone by Bluetooth embedded inside. This portable electrochemical micro-workstation platform exhibits excellent analysis performance. The LODs for Aβ40, Aβ42, T-tau, and P-tau181 are 0.125 pg/mL, 0.089 pg/mL, 0.142 pg/mL, and 0.176 pg/mL, respectively, which satisfies the needs of detecting AD biomarkers in serum. The combination of portable micro-workstation and integrated electrochemical microarray provides a promising strategy for the early diagnosis of Alzheimer's disease and personal healthcare.

Indexed as

Biosensing TechniquesElectrochemical TechniquesAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersHumanstau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAD biomarkersElectrochemical biosensorElectrochemical micro-workstationHigh-throughput detectionMicroarray platformPortable micro-workstation

Identifiers

PMID35129691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.