Evidence map›Paper›PMID 35129682›Full record

ArticleJournal of bone and mineral metabolism2022

Preparation of chitosan-tannic acid coating and its anti-osteoclast and antibacterial activities in titanium implants.

Bo Liao, Cheng Xu, Zhenglun Wang, Wei Li, Xinyu Liu, Dong Lu

Abstract read
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In one paragraph

Article in Journal of bone and mineral metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Effect of graphene-oxide-modified osteon-like concentric microgrooved surface on the osteoclastic differentiation of macrophages.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bo Liao *Key Laboratory for Advanced Technology of Materials of Ministry of Education, Tribology Research Institute, Southwest Jiaotong University, Chengdu, 610031, China.
Cheng Xu *Key Laboratory for Advanced Technology of Materials of Ministry of Education, Tribology Research Institute, Southwest Jiaotong University, Chengdu, 610031, China.
Zhenglun WangKey Laboratory for Advanced Technology of Materials of Ministry of Education, Tribology Research Institute, Southwest Jiaotong University, Chengdu, 610031, China.
Wei LiKey Laboratory for Advanced Technology of Materials of Ministry of Education, Tribology Research Institute, Southwest Jiaotong University, Chengdu, 610031, China. liweijiani@home.swjtu.edu.cn.ORCID http://orcid.org/0000-0003-0510-1540
Xinyu LiuChengdu Advanced Metal Materials Industry Technology Research Institute, Chengdu, 610300, China.
Dong LuChengdu Advanced Metal Materials Industry Technology Research Institute, Chengdu, 610300, China.

Funding

key r & d project of sichuan province 2018JY0552national natural science foundation of china 51675447
6 · The paper itself

Abstract

introductionBacterial infection and aseptic loosening caused by bone resorption at the implant interface are major clinical complications during bone defect implantation surgery, and surface modification of the implant to address the aforementioned problems has long been a research focus. MATERIALS AND

methodsIn this paper, a chitosan (CTS)-tannic acid (TA) colloid coating with a negative charge and excellent hydrophilicity was prepared on a Ti6Al4V (TC4) surface using a layer-by-layer assembly method. The physical properties, anti-osteoclast activity, and antimicrobial activity of the coatings were investigated.

resultsThe findings showed that when the pH value was 5 and the ratio of CTS:TA was 0.8, the carrying rate of TA was the best. Furthermore, the CTS-TA coating had no cytotoxicity on the morphology and proliferation of BMSCs cells and effectively inhibited the differentiation of RAW264.7 cells into osteoclasts and the proliferation of Staphylococcus aureus and Escherichia coli. With the increase in the immersion time of TC4 in CTS-TA colloid solution, the inhibitory effects will also enhance.

conclusionTherefore, the preparation of the CTS-TA coating provides a revolutionary technique for implant surface modification to avoid postoperative bacterial infection and aseptic loosening.

Indexed as

ChitosanTitaniumAnti-Bacterial AgentsCoated Materials, BiocompatibleEscherichia coliOsteoclastsTanninsAnti-Bacterial AgentsChitosanCoated Materials, BiocompatibleTanninsTitaniumAntimicrobial activityAnti-osteoclastsChitosan–tannic acid coatingLayer-by-layer assemblyTi6Al4V

Identifiers

PMID35129682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.