ReviewInvestigative ophthalmology & visual science2022
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
Open access · goldAbstract readReviewConsensus Statement
In one paragraph
Review in Investigative ophthalmology & visual science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
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Who cites it
42 citing papers in PubMed, 55 citations in OpenAlex.
- Schlemm's Canal Development and Implications for Glaucoma Treatment.Annual review of vision science · 2026Review
- Integrin-Linked Kinase Suppression Reduces SPARC's Effect on Intraocular Pressure and Extracellular Matrix.Investigative ophthalmology & visual science · 2026Article
- Effects of Micropulse Laser Trabeculoplasty on Intraocular Pressure and Aqueous Humor Outflow in Pigmented Rabbits.Investigative ophthalmology & visual science · 2026Article
- Topical Administration of Sitagliptin Prevents Retinal Neurodegeneration in a Model of Glaucoma Induced by Dexamethasone.International journal of molecular sciences · 2025Article
- The TRPV4-YAP axis mediates cytoskeletal and extracellular matrix remodeling in trabecular meshwork cells as a novel glaucoma mechanism.Scientific reports · 2025Article
- Intracameral Puncture Lowers Intraocular Pressure and Triggers an Immune Response in the Conventional Outflow Tract.Investigative ophthalmology & visual science · 2025Article
- Hypomethylation of thrombospondin-1 promoter region is associated with reduced aqueous humor flow.Communications biology · 2025Article
- Matrine Reduces Intraocular Pressure in Corticosteroid-Induced Ocular Hypertensive Mouse Eyes.Investigative ophthalmology & visual science · 2025Article
- Article
- TRPV4 controls circadian and pathological ocular hypertension.The Journal of physiology · 2025Article
- TGFβ2 alters segmental outflow and ECM ultrastructure in the trabecular meshwork.Experimental eye research · 2025Article
- Non-invasive real-time pulsed Doppler assessment of blood flow in mouse ophthalmic artery.Cell reports methods · 2025Article
- In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics.Investigative ophthalmology & visual science · 2025Article
- Human Corneal Rim Perfusion Culture.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Intraocular Pressure and Retinal Nerve Fiber Layer Changes in a Microgravity Mouse Model and Relevance to Spaceflight-Associated Neuro-Ocular Syndrome.Eye and brain · 2025Article
- The Inducible TGFβ2 Ocular Hypertension Mouse Model.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The use of vitamin E in ocular health: Bridging omics approaches with Tocopherol and Tocotrienol in the management of glaucoma.Food chemistry. Molecular sciences · 2024Article
- Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches.Investigative ophthalmology & visual science · 2024Article
- Resting trabecular meshwork cells experience constitutive cation influx.Vision research · 2024Article
- Schlemm's canal-selective Tie2/TEK knockdown induces sustained ocular hypertension in adult mice.Experimental eye research · 2024Article
Corrections and comments
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Authors and funding
80 authors at 20 institutions in 5 countries.
Colleen M McDowellDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Krishnakumar KizhatilThe Jackson Laboratory, Bar Harbor, Maine, United States.
Michael H ElliottUniversity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Darryl R OverbyDepartment of Bioengineering, Imperial College London, United Kingdom.
Joseph van Batenburg-SherwoodDepartment of Bioengineering, Imperial College London, United Kingdom.
J Cameron MillarDepartment of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Markus H KuehnDepartment of Ophthalmology and Visual Sciences and Institute for Vision Research, The University of Iowa; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, United States.
Gulab ZodeDepartment of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Ted S AcottOphthalmology and Biochemistry and Molecular Biology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
Michael G AndersonDepartment of Molecular Physiology and Biophysics and Department of Ophthalmology and Visual Sciences, The University of Iowa; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, United States.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, University of Miami, Miami, Florida, United States.
Jacques A BertrandDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Terete BorrasUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Diane E BovenkampBrightfocus Foundation, Clarksburg, Maryland, United States.
Lin ChengDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States.
John DaniasSUNY Downstate Health Sciences University, Brooklyn, New York, United States.
Michael Lucio De IesoDepartment of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina, United States.
Yiqin DuDepartment of Ophthalmology, University of Pittsburgh, Pennsylvania, United States.
Jennifer A FaralliDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Rudolf FuchshoferInstitute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
Preethi S GanapathyDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, United States.
Haiyan GongDepartment of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States.
Samuel HerbergDepartment of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, United States.
Humberto HernandezUniversity of Houston-Victoria, Victoria, Texas, United States.
Peter HumphriesSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Simon W M JohnDepartment of Ophthalmology, Columbia University, New York, New York, United States.
Paul L KaufmanDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Kate E KellerCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
Mary J KelleyDepartment of Ophthalmology and Department of Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, United States.
Ruth A KellyOcular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
David KrizajDepartment of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah, United States.
Ajay KumarDepartment of Ophthalmology, University of Pittsburgh, Pennsylvania, United States.
Brian C LeonardDepartment of Surgical and Radiological Sciences, University of California, Davis, Davis, California, United States.
Raquel L LiebermanDepartment of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States.
Paloma LitonDepartment of Ophthalmology and Department of Pathology, Duke University, Durham, North Carolina, United States.
Yutao LiuDepartment of Cellular Biology and Anatomy, James & Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia, United States.
Katy C LiuDuke Eye Center, Duke Health, Durham, North Carolina, United States.
Navita N LopezDepartment of Neurobiology, University of Utah, Salt Lake City, Utah, United States.
Weiming MaoDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Timur MavlyutovDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Fiona McDonnellDuke Eye Center, Duke Health, Durham, North Carolina, United States.
Gillian J McLellanDepartment of Surgical Sciences and Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Philip MzykDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Andrews NarteyCollege of Optometry, University of Houston, Houston, Texas, United States.
Louis R PasqualeDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States.
Gaurang C PatelOphthalmology Research, Regeneron Pharmaceuticals, Tarreytown, New York, United States.
Padmanabhan P PattabiramanDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Donna M PetersDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Vijaykrishna RaghunathanCollege of Optometry, University of Houston, Houston, Texas, United States.
Ponugoti Vasantha RaoDepartment of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States.
Naga RayanaDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Urmimala RaychaudhuriDepartment of Neurobiology, University of California, Irvine, Irvine, California, United States.
Ester Reina-TorresDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Ruiyi RenDepartment of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States.
Douglas RheeCase Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Uttio Roy ChowdhuryDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States.
John R SamplesWashington State University, Floyd Elson College of Medicine, Spokane, Washington, United States.
E Griffen SamplesWestern Glaucoma Foundation, Sisters, Oregon, United States.
Najam SharifSanten Inc., Emeryville, California, United States.
Joel S SchumanDepartment of Ophthalmology and Department of Physiology and Neuroscience, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, New York, United States; Departments of Biomedical Engineering and Electrical and Computer Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States; Center for Neural Science, College of Arts and Science, New York University, New York, New York, United States.
Val C SheffieldDepartment of Pediatrics and Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.
Cooper H StevensonDepartment of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Avinash SoundararajanDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Preeti SubramanianBrightfocus Foundation, Clarksburg, Maryland, United States.
Chenna Kesavulu SugaliDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Yang SunVeterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, California, United States.
Carol B TorisDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States; Department of Ophthalmology and Vision Sciences, The Ohio State University, Columbus, Ohio, United States.
Karen Y TorrejonGlauconix Biosciences, Albany, New York, United States.
Amir VahabikashiCell and Developmental Biology Department, Northwestern University, Chicago, Illinois, United States.
Janice A VrankaDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
Ting WangDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Colin E WilloughbyGenomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, United Kingdom.
Chen XinBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Hongmin YunDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Hao F ZhangBiomedical Engineering Department, Northwestern University, Evanston, Illinois, United States.
Michael P FautschBiomedical Engineering Department, Northwestern University, Evanston, Illinois, United States.
Ernst R TammUniversity of Regensburg, Regensburg, Germany.
Abbot F ClarkDepartment of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States.
C Ross EthierWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology; Emory University School of Medicine, Emory University, Atlanta, Georgia, United States.
W Daniel StamerDuke Ophthalmology, Duke University, Durham, North Carolina, United States.
University of Wisconsin–Madison · USIndiana University – Purdue University Indianapolis · USDuke University · USImperial College London · GBOregon Health & Science University · USUniversity of Iowa · USNorthwestern University · USUniversity of Pittsburgh · USBoston University · USGeorgia Institute of Technology · USSUNY Upstate Medical University · USTrinity College Dublin · IEUniversity of Houston · USUniversity of North Texas · USUniversity of North Texas Health Science Center · USUniversity of Regensburg · DEUniversity of Utah · USCapital Medical University · CNCase Western Reserve University · USColumbia University · US
Funding
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell · 1995 to 2026
$19.4MVISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3MNovel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5MUniversity of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6MRequest for Supplement to Promote Diversity in Health Related ResearchR01EY021205 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Raquel L Lieberman · 2011 to 2026
$6.8MControl of Trabecular Meshwork CytoskeletonR01EY017006 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, DONNA M · 2006 to 2024
$6.1MTrabecular Meshwork Cytoskeletal Signaling-Regulation of Aqueous Humor OutflowR01EY018590 · NEI · DUKE UNIVERSITY · PI RAO, P VASANTHA · 2008 to 2022
$5.6MExtracellular Matrix and Outflow ResistanceR01EY019643 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLER, KATE E · 2010 to 2025
$5.0MAutophagy and Mechanotransduction in the Trabecular MeshworkR01EY026885 · NEI · DUKE UNIVERSITY · PI Paloma Liton · 2016 to 2026
$4.7MMechanisms of Trabecular Meshwork Regeneration by Stem CellsR01EY025643 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI Yiqin Du · 2015 to 2026
$4.2MIntraocular pressure regulation via ATP-sensitive potassium channelsR01EY021727 · NEI · MAYO CLINIC ROCHESTER · PI FAUTSCH, MICHAEL P. · 2011 to 2021
$4.1MCrosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8MNEI NIH HHS K99 EY032547NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY010572NEI NIH HHS P30 EY014800NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY017006NEI NIH HHS R01 EY018590NEI NIH HHS R01 EY019643NEI NIH HHS R01 EY021205NEI NIH HHS R01 EY021727NEI NIH HHS R01 EY022634NEI NIH HHS R01 EY025543NEI NIH HHS R01 EY025643NEI NIH HHS R01 EY025721NEI NIH HHS R01 EY026048NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY026529NEI NIH HHS R01 EY026885NEI NIH HHS R01 EY026962NEI NIH HHS R01 EY027733NEI NIH HHS R01 EY027920NEI NIH HHS R01 EY028616NEI NIH HHS R01 EY029320NEI NIH HHS R01 EY030238NEI NIH HHS R01 EY031700NEI NIH HHS R01 EY031817NEI NIH HHS R01 EY032905NEI NIH HHS R01 EY032960NEI NIH HHS R01 EY034534NEI NIH HHS R21 EY028671NEI NIH HHS R21 EY033073RRD VA I01 RX001163RRD VA I01 RX002860
Abstract
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
Indexed as
AnimalsAqueous HumorDisease Models, AnimalGlaucomaIntraocular PressureMiceOcular HypertensionTonometry, OcularTrabecular Meshwork
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.