ArticleAnnals of surgery2023
Postoperative Opioid Prescribing and New Persistent Opioid Use: The Risk of Excessive Prescribing.
Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Social Worker Presence in Outpatient Fracture Clinics: A Batched Stepped-Wedge Cluster Randomized Trial
SAVE Trial: SAfe Opioid Use Video Education
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Unveiling Prescribing Patterns: A Systematic Review of Chronic Opioid Prescriptions After Head and Neck Cancer Surgeries.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Pooled it
- Clinical Decision Support to Reduce Opioid Prescribing at Discharge for Inpatients Undergoing Surgery (LESS Study): An Interrupted Time Series Analysis.Anesthesiology · 2026Article
- The effect of surgical approach on opioid prescription rates for outpatient ventral hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Association of Perioperative Cannabis Use With Postoperative Opioid Consumption in Ankle Fracture Patients.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Treatment gaps for opioid use disorder among commercially insured US surgical patients, 2016-2022.Regional anesthesia and pain medicine · 2026Article
- Association of robotic surgical approach with decreased inpatient opioid exposure after abdominal wall reconstruction: a retrospective cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Opioid consumption in the first 30 days after surgery was independently associated with new persistent opioid use.Regional anesthesia and pain medicine · 2026Article
- Association of patient-reported substance use and postoperative pain.Regional anesthesia and pain medicine · 2026Article
- Factors driving higher opioid use after total hip arthroplasty: Insights from a large-scale, tertiary centre analysis.SICOT-J · 2026Article
- Benefits of enhanced recovery after surgery in robotic nephrectomy.World journal of urology · 2025Article
- Prevalence and Acceptability of Dedicated Social Work Support in the Fracture Clinic: A Survey of Orthopaedic Trauma Surgeons.Scandinavian journal of caring sciences · 2025Article
- Association of Opioid Prescribing and Consumption with Patient-reported Experiences and Satisfaction After Emergency Surgery in Michigan.Annals of surgery · 2025Article
- Predicting postoperative chronic opioid use with fair machine learning models integrating multi-modal data sources: a demonstration of ethical machine learning in healthcare.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Impact of COVID-19 on Opioid Prescribing, Consumption, Pain, and Outcomes after Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- An automated group-housed oral fentanyl self-administration method in mice.Psychopharmacology · 2025Article
- Gabapentin as an adjunct to multimodal pain management following scrotal surgery.Translational andrology and urology · 2025Article
- Creating a Framework for Minimizing Opioid Consumption after Office Based Surgery.Current pain and headache reports · 2025Review
- Opioid Prescriptions for US Patients Undergoing Long-Term Dialysis or with Kidney Transplant from 2011 to 2020.Journal of the American Society of Nephrology : JASN · 2025Article
- Opioid consumption before discharge predicts outpatient opioid use in adolescents undergoing surgery.Surgery · 2024Article
- Long-term Health Outcomes of New Persistent Opioid Use After Gastrointestinal Cancer Surgery.Annals of surgical oncology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveEvaluate the association between postoperative opioid prescribing and new persistent opioid use. SUMMARY BACKGROUND DATA: Opioid-nave patients who develop new persistent opioid use after surgery are at increased risk of opioid-related morbidity and mortality. However, the extent to which postoperative opioid prescribing is associated with persistent postoperative opioid use is unclear.
methodsRetrospective study of opioid-naïve adults undergoing surgery in Michigan from 1/1/2017 to 10/31/2019. Postoperative opioid prescriptions were identified using a statewide clinical registry and prescription fills were identified using Michigan's prescription drug monitoring program. The primary outcome was new persistent opioid use, defined as filling at least 1 opioid prescription between post-discharge days 4 to 90 and filling at least 1 opioid prescription between post-discharge days 91 to 180.
resultsA total of 37,654 patients underwent surgery with a mean age of 52.2 (16.7) years and 20,923 (55.6%) female patients. A total of 31,920 (84.8%) patients were prescribed opioids at discharge. Six hundred twenty-two (1.7%) patients developed new persistent opioid use after surgery. Being prescribed an opioid at discharge was not associated with new persistent opioid use [adjusted odds ratio (aOR) 0.88 (95% confidence interval (CI) 0.71-1.09)]. However, among patients prescribed an opioid, patients prescribed the second largest [12 (interquartile range (IQR) 3) pills] and largest [20 (IQR 7) pills] quartiles of prescription size had higher odds of new persistent opioid use compared to patients prescribed the smallest quartile [7 (IQR 1) pills] of prescription size [aOR 1.39 (95% CI 1.04-1.86) andaOR 1.97 (95% CI 1.442.70), respectively].
conclusionsIn a cohort of opioid-naïve patients undergoing common surgical procedures, the risk of new persistent opioid use increased with the size of the prescription. This suggests that while opioid prescriptions in and of themselves may not place patients at risk of long-term opioid use, excessive prescribing does. Consequently, these findings support ongoing efforts to mitigate excessive opioid prescribing after surgery to reduce opioid-related harms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.