Evidence map›Paper›PMID 35129437›Full record

ArticleeLife2022

SWI/SNF senses carbon starvation with a pH-sensitive low-complexity sequence.

J Ignacio Gutierrez, Gregory P Brittingham, Yonca Karadeniz, Kathleen D Tran, Arnob Dutta, Alex S Holehouse, Craig L Peterson, Liam J Holt

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  6. Control of Inflammatory Response by Tissue Microenvironment.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
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  16. Article
  17. Review
  18. Article
  19. Increased mesoscale diffusivity in response to acute glucose starvation.bioRxiv : the preprint server for biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J Ignacio GutierrezDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-9017-8384
Gregory P BrittinghamInstitute for Systems Genetics, New York University Grossman School of Medicine, New York, United States.
Yonca KaradenizProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-8299-551X
Kathleen D TranDepartment of Cell and Molecular Biology, University of Rhode Island, Kingston, United States.
Arnob DuttaDepartment of Cell and Molecular Biology, University of Rhode Island, Kingston, United States.
Alex S HolehouseCenter for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St Louis, United States.ORCID 0000-0002-4155-5729
Craig L PetersonProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, United States.
Liam J HoltInstitute for Systems Genetics, New York University Grossman School of Medicine, New York, United States.ORCID 0000-0002-4002-0861

Funding

Regulation of chromatin dynamicsR35GM122519 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Craig L Peterson · 2017 to 2026
$9.2M
Cancer under pressure: Mechanisms of adaptation to compressive stressR37CA240765 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2025
$3.2M
Tools to probe the biophysical properties of cellsR01GM132447 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2022
$2.1M
Howard Hughes Medical InstituteNCI NIH HHS R37 CA240765NIGMS NIH HHS R01 GM132447NIGMS NIH HHS R35 GM122519
6 · The paper itself

Abstract

It is increasingly appreciated that intracellular pH changes are important biological signals. This motivates the elucidation of molecular mechanisms of pH sensing. We determined that a nucleocytoplasmic pH oscillation was required for the transcriptional response to carbon starvation in

Indexed as

Chromosomal Proteins, Non-HistoneSaccharomyces cerevisiae ProteinsCarbonChromatin Assembly and DisassemblyHydrogen-Ion ConcentrationSaccharomyces cerevisiaeTranscription FactorsCarbonChromosomal Proteins, Non-HistoneSaccharomyces cerevisiae ProteinsTranscription Factorsbiochemistrychemical biologychromatinchromosomesgene expressionlow-complexity sequencespHpolyglutamineS. cerevisiaetranscription

Identifiers

PMID35129437
PMCPMC8890752

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.