Evidence map›Paper›PMID 35129367›Full record

ArticlePhysiological reviews2022

The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021.

Scott Earley, L Fernando Santana, W Jonathan Lederer

Abstract readEditorial
In one paragraph

Article in Physiological reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. The physiology of survival: Heat.Experimental physiology · 2026
    Article
  2. Article
  3. Podocyte-specific deletion of mechanochannel Piezo1 exacerbates proteinuria and podocyte injury in mouse hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  4. Review
  5. TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026
    Article
  6. Article
  7. Review
  8. The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  14. TRPA1-Related Diseases and Applications of Nanotherapy.International journal of molecular sciences · 2024
    Review
  15. Capsaicin: Emerging Pharmacological and Therapeutic Insights.Current issues in molecular biology · 2024
    Review
  16. TRP Ion Channels in Immune Cells and Their Implications for Inflammation.International journal of molecular sciences · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Mechanosensitive channels in lung disease.Frontiers in physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Scott EarleyDepartment of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.ORCID 0000-0001-9560-2941
L Fernando SantanaDepartment of Physiology and Membrane Biology, University of California, Davis, California.ORCID 0000-0002-4297-8029
W Jonathan LedererDepartment of Physiology and Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, Maryland.

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Mitchell Hamed Omar · 2019 to 2026
$20.3M
Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
NFAT-induced Regional Variations in Kv4 Channel Expression in HeartR01HL085686 · NHLBI · UNIVERSITY OF WASHINGTON · PI SANTANA, LUIS F · 2007 to 2020
$5.7M
TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5M
Mechanisms of Functional Vascular Impairment In Genetic Models of Cerebral Small Vessel DiseaseRF1NS110044 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EARLEY, SCOTT, GOULD, DOUGLAS · 2018 to 2022
$3.3M
Chemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6M
Diversity Supplement-MassoudiR33NS115132 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, EARLEY, SCOTT · 2021 to 2023
$2.6M
Multi-Scale Modeling of Vascular Signaling UnitsR01HL152681 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2020 to 2023
$2.4M
Tuning L-Type Ca Channel Activity in Arterial Smooth Muscle by Kv Channel-Mediated ClusteringR01HL144071 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANTANA, LUIS F, TRIMMER, JAMES S · 2018 to 2021
$2.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R35HL155008HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM130459HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R33NS115132HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1NS110044HHS | NIH | OSC | Common Fund (NIH Common Fund) OT2OD026580NHLBI NIH HHS R01 HL085686NHLBI NIH HHS R01 HL142290NHLBI NIH HHS R01 HL144071NHLBI NIH HHS R01 HL152681NHLBI NIH HHS R35 HL155008
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Nobel PrizeHumansNobel PrizePiezo channelspressuretemperatureTRP channels

Identifiers

PMID35129367
PMCPMC8917909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.