ArticleHuman brain mapping2022
Multimodal data integration via mediation analysis with high-dimensional exposures and mediators.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trends in AI-based diagnosis and intervention of metabolic diseases: a bibliometric analysis of the literature from 2000 to 2024.Frontiers in medicine · 2025Pooled it
- Sparse CCA-based mediation analysis with high-dimensional exposures and mediators.Bioinformatics (Oxford, England) · 2026Article
- Microbial enterotype is linked to episodic and working memories via brain function in the parietal and occipital cortices.BMC biology · 2026Article
- ESPLSM: An Efficient and Interpretable Mediation Analysis Framework Using Sparse Envelopes.Statistics in medicine · 2026Article
- Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026Article
- HILAMA: High-dimensional multi-omics mediation analysis with latent confounding.BMC medical research methodology · 2025Article
- Non-Traditional Lipid Parameters and Risk of Adverse Pregnancy Outcomes in Gestational Diabetes Mellitus: Mediation by Maternal Metabolites.Journal of diabetes · 2025Observational
- S-GMAS: Genome-Wide Mediation Analysis With Brain Subcortical Shape Mediators.Human brain mapping · 2025Article
- MULTIVARIATE DYNAMIC MEDIATION ANALYSIS UNDER A REINFORCEMENT LEARNING FRAMEWORK.Annals of statistics · 2025Article
- A novel strategy for detecting multiple mediators in high-dimensional mediation models.Frontiers in psychiatry · 2025Article
- Mediation Analysis with Multiple Exposures and Multiple Mediators.Statistics in medicine · 2024Article
- The Influence of Structural Brain Changes on Cognition in the Context of Healthy Aging: Exploring Mediation Effects Through gBAT-The Graphical Brain Association Tool.Human brain mapping · 2024Article
- Instrumental variable-based high-dimensional mediation analysis with unmeasured confounders for survival data in the observational epigenetic study.Frontiers in genetics · 2023Article
- DNA methylation and aeroallergen sensitization: The chicken or the egg?Clinical epigenetics · 2022Article
- Multimodal data integration via mediation analysis with high-dimensional exposures and mediators.Human brain mapping · 2022Article
- Brain morphology mediating the effects of common genetic risk variants on Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
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Authors and funding
3 authors.
Funding
Abstract
Motivated by an imaging proteomics study for Alzheimer's disease (AD), in this article, we propose a mediation analysis approach with high-dimensional exposures and high-dimensional mediators to integrate data collected from multiple platforms. The proposed method combines principal component analysis with penalized least squares estimation for a set of linear structural equation models. The former reduces the dimensionality and produces uncorrelated linear combinations of the exposure variables, whereas the latter achieves simultaneous path selection and effect estimation while allowing the mediators to be correlated. Applying the method to the AD data identifies numerous interesting protein peptides, brain regions, and protein-structure-memory paths, which are in accordance with and also supplement existing findings of AD research. Additional simulations further demonstrate the effective empirical performance of the method.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.