Evidence map›Paper›PMID 35129170›Full record

ArticleJournal of visualized experiments : JoVE2022

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning.

Gerard Joey Broussard, Mikhail Kislin, Caroline Jung, Samuel S-H Wang

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerard Joey BroussardNeuroscience Institute, Princeton University.
Mikhail KislinNeuroscience Institute, Princeton University.
Caroline JungNeuroscience Institute, Princeton University.
Samuel S-H WangNeuroscience Institute, Princeton University; sswang@princeton.edu.

Funding

Imaging adaptive cerebellar processing at cellular resolution in awake miceR01NS045193 · NINDS · PRINCETON UNIVERSITY · PI WANG, SAMUEL SHENG-HUNG · 2003 to 2024
$7.5M
Cerebellar determinants of flexible and social behavior on rapid time scales in autism model mice.R01MH115750 · NIMH · PRINCETON UNIVERSITY · PI PILLOW, JONATHAN WILLIAM, SHAEVITZ, JOSHUA W · 2017 to 2021
$4.7M
Mapping cerebellar granule cell function with novel genetic and optical toolsF32MH120887 · NIMH · PRINCETON UNIVERSITY · PI BROUSSARD, GERARD JOEY · 2019 to 2021
$213k
NIMH NIH HHS F32 MH120887NIMH NIH HHS R01 MH115750NINDS NIH HHS R01 NS045193
6 · The paper itself

Abstract

Climbing fiber inputs to Purkinje cells provide instructive signals critical for cerebellum-dependent associative learning. Studying these signals in head-fixed mice facilitates the use of imaging, electrophysiological, and optogenetic methods. Here, a low-cost behavioral platform (~$1000) was developed that allows tracking of associative learning in head-fixed mice that locomote freely on a running wheel. The platform incorporates two common associative learning paradigms: eyeblink conditioning and delayed tactile startle conditioning. Behavior is tracked using a camera and the wheel movement by a detector. We describe the components and setup and provide a detailed protocol for training and data analysis. This platform allows the incorporation of optogenetic stimulation and fluorescence imaging. The design allows a single host computer to control multiple platforms for training multiple animals simultaneously.

Indexed as

CerebellumPurkinje CellsAnimalsBlinkingConditioning, ClassicalMiceOptogenetics

Identifiers

PMID35129170
PMCPMC9118201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.