Evidence map›Paper›PMID 35129072›Full record

ArticleGut microbes

Hesuiyuan Wang, Qing Wang, Chengmao Yang, Mingming Guo, Xiaoyue Cui, Zhe Jing, Yujie Liu, Wanjin Qiao, Hang Qi, Hongyang Zhang and 9 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Interplays ofNutrients · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Acta pharmaceutica Sinica. B · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Hesuiyuan WangCollege of Life Sciences, Nankai University, Tianjin, China.
Qing WangCollege of Life Sciences, Nankai University, Tianjin, China.
Chengmao YangCollege of Life Sciences, Nankai University, Tianjin, China.
Mingming GuoCollege of Life Sciences, Nankai University, Tianjin, China.
Xiaoyue CuiCollege of Life Sciences, Nankai University, Tianjin, China.
Zhe JingCollege of Life Sciences, Nankai University, Tianjin, China.
Yujie LiuCollege of Life Sciences, Nankai University, Tianjin, China.
Wanjin QiaoCollege of Life Sciences, Nankai University, Tianjin, China.
Hang QiCollege of Life Sciences, Nankai University, Tianjin, China.
Hongyang ZhangCollege of Life Sciences, Nankai University, Tianjin, China.
Xu ZhangCollege of Life Sciences, Nankai University, Tianjin, China.
Na ZhaoDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Mengjuan ZhangCollege of Life Sciences, Nankai University, Tianjin, China.
Min ChenCollege of Life Sciences, Nankai University, Tianjin, China.
Song ZhangCollege of Life Sciences, Nankai University, Tianjin, China.
Haijin XuCollege of Life Sciences, Nankai University, Tianjin, China.
Liqing ZhaoCollege of Life Sciences, Nankai University, Tianjin, China.
Mingqiang QiaoCollege of Life Sciences, Nankai University, Tianjin, China.
Zhenzhou WuCollege of Life Sciences, Nankai University, Tianjin, China.ORCID 0000-0002-1934-1361
Nankai University · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal flora plays an important role in the development of many human and animal diseases. Microbiome association studies revealed the potential regulatory function of intestinal bacteria in many liver diseases, such as autoimmune hepatitis, viral hepatitis and alcoholic hepatitis. However, the key intestinal bacterial strains that affect pathological liver injury and the underlying functional mechanisms remain unclear. We found that the gut microbiota from gentamycin (Gen)-treated mice significantly alleviated concanavalin A (ConA)-induced liver injury compared to vancomycin (Van)-treated mice by inhibiting CD95 expression on the surface of hepatocytes and reducing CD95/CD95L-mediated hepatocyte apoptosis. Through the combination of microbiota sequencing and correlation analysis, we isolated 5 strains with the highest relative abundance,

Indexed as

Gastrointestinal MicrobiomeAnimalsApoptosisBacteriaBacteroidesfas ReceptorFecesGlutathioneHepatocytesHumansLiver DiseasesMiceMice, Inbred C57BLfas ReceptorGlutathioneCD95GSHgut microbiotaHepatitisintestinal flora dysbiosis

Identifiers

PMID35129072
PMCPMC8820816
OpenAlexW4210801559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.