Evidence map›Paper›PMID 35128838›Full record

ArticleActa ophthalmologica2022

Flicker-induced retinal vascular dilation in ipsi- and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study.

Marianne Ala-Kauhaluoma, Pirkka Vikatmaa, Suvi M Koskinen, Petra Ijäs, Krista Nuotio, Heli Silvennoinen, Kristiina Relander, Perttu J Lindsberg, Lauri Soinne, Paula A Summanen

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In one paragraph

Article in Acta ophthalmologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marianne Ala-KauhaluomaDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID https://orcid.org/0000-0001-7871-5493
Pirkka VikatmaaDepartment of Vascular surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Suvi M KoskinenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Petra IjäsDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Krista NuotioDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Heli SilvennoinenDepartment of Radiology, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kristiina RelanderDepartment of Neuropsychology, HUS Neurocenter, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Perttu J LindsbergDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Lauri SoinneDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Paula A SummanenDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID https://orcid.org/0000-0002-0028-5056
University of Helsinki · FI

Funding

Evald ja Hilda Nissin SäätiöMary och Georg C. Ehrnrooths Stiftelse 202100016Silmä- ja kudospankkisäätiöSilmäsäätiöSuomen Silmälääkäriyhdistyksen
6 · The paper itself

Abstract

purposeRetinal vascular function was assessed in patients with carotid stenosis (CS) before and six months after carotid endarterectomy (CEA) and in controls at a six-month interval.

methodsWe studied 68 patients (81% male, mean age 69) and 41 healthy non-medicated controls (77%, 68) from March 2015 to December 2018. Our ophthalmological examination included flicker-induced arteriolar and venular measurements with a Dynamic Vessel Analyser in both eyes.

resultsAt baseline, flicker-induced arteriolar and venular dilation was reduced in the ipsilateral eyes of the patients compared with dilation in the controls (arteriolar 1.0% versus 2.6%, p = 0.001 and venular 2.2% versus 2.8%, p = 0.049). These differences subsided after CEA. In patients' ipsilateral eyes, flicker-induced arteriolar dilation was borderline postoperatively (preoperative 1.0% versus postoperative 1.6%, p = 0.06), whereas venular dilation increased (2.2% versus 2.8%, p = 0.025). We found various tentative associations with the change in flicker-induced dilations after CEA, but not with the preoperative dilations.

conclusionsPostoperative recovery of the reduced flicker-induced arteriolar and venular dilatation in the ipsilateral eye shows that, after CEA, the activity-dependent vascular reactivity of haemodynamically compromised retinal tissue can improve.

Indexed as

Carotid StenosisEndarterectomy, CarotidAgedDilatationFemaleHumansMaleProspective StudiesRetinal Vesselscarotid endarterectomycarotid stenosisdynamic vessel analyzerflicker-induced retinal vasodilation

Identifiers

PMID35128838
PMCPMC9790524
OpenAlexW4210292731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.