Evidence map›Paper›PMID 35128691›Full record

ArticleClinical cardiology2022

Comparative effects of left bundle branch area pacing, His bundle pacing, biventricular pacing in patients requiring cardiac resynchronization therapy: A network meta-analysis.

Juan Hua, Chenxi Wang, Qiling Kong, Yichu Zhang, Qijun Wang, Ziyi Xiong, Jinzhu Hu, Juxiang Li, Qi Chen, Kui Hong

Open access · goldAbstract readNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 7 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 7 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Conduction system pacing for cardiac resynchronization therapy: a systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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  15. Conduction System Pacing for Cardiac Resynchronization Therapy.Journal of cardiovascular development and disease · 2023
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  17. Abnormal Conduction-Induced Cardiomyopathy: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Juan HuaDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Chenxi WangDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Qiling KongDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Yichu ZhangDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Qijun WangDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Ziyi XiongDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jinzhu HuDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Juxiang LiDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Qi ChenDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Kui HongDepartment of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Nanchang University · CNSecond Affiliated Hospital of Nanchang University · CN

Funding

National Natural Science Foundation of China 81360025
6 · The paper itself

Abstract

backgroundThe comparative effects of different types of cardiac resynchronization therapy (CRT) delivered by biventricular pacing (BVP), His bundle pacing (HBP), and left bundle branch area pacing (LBBAP) remain inconclusive. HYPOTHESIS: HBP and LBBAP may be advantageous over BVP for CRT.

methodsPubMed, Embase, Web of Science, and the Cochrane Library were systematically searched for studies that reported the effects after BVP, HBP, and LBBAP for CRT. The effects between groups were compared by a frequentist random-effects network meta-analysis (NMA), by which the mean differences (MDs) and 95% confidence intervals (CIs) were calculated.

resultsSix articles involving 389 patients remained for the final meta-analysis. The mean follow-up of these studies was 8.03 ± 3.15 months. LBBAP resulted in a greater improvement in LVEF% (MD = 7.17, 95% CI = 4.31 to 10.04), followed by HBP (MD = 4.06, 95% CI = 1.09 to 7.03) compared with BVP. HBP resulted in a narrower QRS duration (MD = 31.58 ms, 95% CI = 12.75 to 50.40), followed by LBBAP (MD = 27.40 ms, 95% CI = 10.81 to 43.99) compared with BVP. No significant differences of changes in LVEF improvement and QRS narrowing were observed between LBBAP and HBP. The pacing threshold of LBBAP was significantly lower than those of BVP and HBP.

conclusionThe NMA first found that LBBAP and HBP resulted in a greater LVEF improvement and a narrower QRS duration compared with BVP. Additionally, LBBAP resulted in similar clinical outcomes but with lower pacing thresholds, and may therefore offer advantages than does HBP for CRT.

Indexed as

Cardiac Resynchronization TherapyBundle of HisCardiac Pacing, ArtificialElectrocardiographyHumansTreatment Outcomebiventricular pacingcardiac resynchronization therapyHis bundle pacingleft bundle branch area pacingnetwork meta-analysis

Identifiers

PMID35128691
PMCPMC8860481
OpenAlexW4210918080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.