Evidence map›Paper›PMID 35128621›Full record

ArticleEating and weight disorders : EWD2022

Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study.

R Bou Khalil, N Risch, G Sleilaty, S Richa, M Seneque, P Lefebvre, A Sultan, A Avignon, L Maimoun, E Renard and 2 more

Abstract read
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In one paragraph

Article in Eating and weight disorders : EWD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Longitudinal Baboon (Veterinary sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

R Bou KhalilDepartment of Psychiatry, Saint Joseph University-Hôtel Dieu de France Hospital, Beirut, Lebanon. rami.boukhalil@usj.edu.lb.ORCID http://orcid.org/0000-0003-1725-4755
N RischInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
G SleilatyClinical Research Center and Department of Cardiac and Thoracic Surgery, Saint Joseph University-Hôtel Dieu de France Hospital, Beirut, Lebanon.
S RichaDepartment of Psychiatry, Saint Joseph University-Hôtel Dieu de France Hospital, Beirut, Lebanon.
M SenequeInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
P LefebvreDepartment of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, University of Montpellier, Montpellier, France.
A SultanUniversity of Montpellier, PhyMedExp, INSERM, CNRS UMR, CHRU Montpellier, Montpellier, France.
A AvignonDesbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, CHU, Montpellier, France.
L MaimounUniversity of Montpellier, PhyMedExp, INSERM, CNRS UMR, CHRU Montpellier, Montpellier, France.
E RenardInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
P CourtetInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
S GuillaumeInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.

Funding

Centre Hospitalier Régional Universitaire de Montpellier UF8854Centre Hospitalier Régional Universitaire de Montpellier UF9804
6 · The paper itself

Abstract

purposeAnorexia nervosa (AN) is a serious mental illness. It is frequently accompanied by a history of childhood maltreatment (CM) that may constitute a specific ecophenotype in patients with eating disorders necessitating special assessment and management. This retrospective study tested whether in patients with AN, CM-related chronic stress may manifest through low-grade inflammation reflected by an increase in white blood cell ratios (neutrophil-to-lymphocyte ratio, NLR, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio).

methodsParticipants (N = 206) were enrolled at an eating disorder daycare unit in Montpellier, France, from March 2013 and January 2020. CM was assessed using the childhood trauma questionnaire (CTQ). The Eating Disorder Examination Questionnaire (EDE-Q) and the MINI were used to assess AN severity and the other clinical characteristics, respectively.

resultsNLR was higher in patients with AN and history of CM (p = 0.029) and in patients with AN and history of emotional abuse (p = 0.021), compared with patients with AN without history of CM. In multivariate analysis, emotional abuse (β = 0.17; p = 0.027) contributed significantly to NLR variability.

conclusionIn patients with AN, NLR is a low-grade inflammation marker that is influenced by various sociodemographic, clinical and biological factors. It is more directly affected by some CM types, especially emotional abuse, than by the presence/absence of CM history. Future studies should focus on mediators between CM and increased inflammation, such as interoceptive awareness, emotional dysregulation, food addiction, and stress sensitization. LEVEL OF EVIDENCE: III. Evidence obtained from well-designed cohort or case-control analytic studies.

Indexed as

Anorexia NervosaChild AbuseChildCohort StudiesHumansInflammationLymphocytesNeutrophilsRetrospective StudiesAnorexia nervosaChildhood traumaEmotional abuseInflammationNLR

Identifiers

PMID35128621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.