Evidence map›Paper›PMID 35128618›Full record

ArticleCellular and molecular neurobiology2023

BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity.

Clarissa Ribeiro Bastos, Janaina Xavier, Laísa Camerini, Samantha Seibt Dewes, Fernanda Pedrotti Moreira, Carolina David Wiener, Karen Jansen, Manuella Pinto Kaster, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Deletion ofFrontiers in cellular neuroscience · 2026
    Article
  2. Deletion ofbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Clarissa Ribeiro BastosLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-0868-7877
Janaina XavierLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-8061-857X
Laísa CameriniLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-4811-7887
Samantha Seibt DewesLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-4931-0291
Fernanda Pedrotti MoreiraLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-3672-7231
Carolina David WienerLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-4705-3663
Karen JansenLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-3494-8070
Manuella Pinto KasterDepartment of Biochemistry at the Federal University of Santa Catarina, Florianópolis, Brazil.ORCID http://orcid.org/0000-0003-0258-6204
Luciano Dias de Mattos SouzaLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-9965-4837
Ricardo Azevedo da SilvaLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-9114-7037
Jean Pierre OsesPost Graduation Program of Physiological Science, Federal University of Rio Grande, Rio Grande, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-2012-273X
Luis Valmor PortelaDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0001-6113-8466
Diogo Rizzato LaraDepartment of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-6690-9490
Luciana Tovo-RodriguesPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-8732-6059
Gabriele GhisleniLaboratory of Clinical Neuroscience, Post-Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil. gabriele.ghisleni@ucpel.edu.br.ORCID http://orcid.org/0000-0002-1764-6882
Universidade Católica de Pelotas · BRPontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Federal de Pelotas · BRUniversidade Federal de Santa Catarina · BRUniversidade Federal do Rio Grande · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

PRONEX-FAPERGS (08/2009 - PronexPRONEX-FAPERGS grant number 10/0055-0).
6 · The paper itself

Abstract

The CACNA1C gene encodes the pore-forming alpha-1c subunit of L-type voltage-gated calcium channels. The calcium influx through these channels regulates the transcription of the brain-derived neurotrophic factor (BDNF). Polymorphisms in this gene have been consistently associated with psychiatric disorders, and alterations in BDNF levels are a possible biological mechanism to explain such associations. Here, we sought to investigate the effect of the CACNA1C rs1006737 and rs4765913 polymorphisms and their haplotypes on serum BDNF concentration. We further aim to investigate the regulatory function of these SNPs and the ones linked to them. The study enrolled 641 young adults (362 women and 279 men) in a cross-sectional population-based survey. Linear regression was used to test the effects of polymorphisms and haplotypes on BDNF levels adjusted for potential confounders. Moreover, regulatory putative functional roles were assessed using in silico approach. BDNF levels were not associated with CACNA1C polymorphisms/haplotype in the total sample. When the sample was stratified by sex, checking the effect of polymorphisms on men and women separately, the A-allele of rs4765913 was associated with lower BDNF levels in women compared with the TT genotype (p = 0.010). The AA (rs1006737-rs4765913) haplotype was associated with BDNF levels in opposite directions regarding sex, with lower levels of BDNF in women (p = 0.040) compared to those without this haplotype, while with higher levels in men (p = 0.027). These findings were supported by the presence of regulatory marks only on the male fetal brain. Our results suggest that the BDNF levels regulation may be a potential mechanism underpinning the association between CACNA1C and psychiatric disorders, with a differential role in women and men.

Indexed as

Brain-Derived Neurotrophic FactorGenetic Predisposition to DiseaseCalcium Channels, L-TypeCross-Sectional StudiesFemaleHumansMalePolymorphism, Single NucleotideYoung AdultBrain-Derived Neurotrophic FactorCACNA1C protein, humanCalcium Channels, L-TypeBrain-derived neurotrophic factorCalcium channels L-typePolymorphismsSex differences

Identifiers

PMID35128618
PMCPMC11415201
OpenAlexW4210530247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.