Evidence map›Paper›PMID 35128535›Full record

ArticleEJHaem2021

Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease.

Emaan Madany, June Lee, Chelsea Halprin, Jina Seo, Nicole Baca, Fataneh Majlessipour, Jeanne E Hendrickson, Samuel H Pepkowitz, Chelsea Hayes, Ellen Klapper and 1 more

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. The Immunology of Transfusion Medicine: Past, Present, and Future.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Emaan MadanyCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
June LeeCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
Chelsea HalprinCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
Jina SeoCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
Nicole BacaCedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, United States.
Fataneh MajlessipourCedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, United States.
Jeanne E HendricksonDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, United States.
Samuel H PepkowitzCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
Chelsea HayesCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
Ellen KlapperCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.
David R GibbCedars-Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles, California, United States.ORCID 0000-0001-5863-3239
Cedars-Sinai Medical Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Responsiveness and non-responsiveness to transfused RBCs in mice and humans.R01HL132951 · NHLBI · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 2017 to 2020
$1.7M
The role of type 1 interferon in regulating alloimmune responses to transfused red blood cellsK08HL141446 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GIBB, DAVID R · 2018 to 2022
$820k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K08 HL141446NHLBI NIH HHS R01 HL132951
6 · The paper itself

Abstract

Patients with sickle cell disease (SCD) have a high prevalence of RBC alloimmunization. However, underlying mechanisms are poorly understood. Given that proinflammatory type 1 interferons (IFN

Indexed as

alloimmunizationsickle cell diseasetype 1 interferons

Identifiers

PMID35128535
PMCPMC8813163
OpenAlexW3186568922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.