Evidence map›Paper›PMID 35128489›Full record

ArticleJVS-vascular science2022

Vascular smooth muscle cell phenotype switching in carotid atherosclerosis.

Elizabeth L Chou, Christian L Lino Cardenas, Mark Chaffin, Alessandro D Arduini, Dejan Juric, James R Stone, Glenn M LaMuraglia, Matthew J Eagleton, Mark F Conrad, Eric M Isselbacher and 2 more

Open access · goldAbstract read
In one paragraph

Article in JVS-vascular science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Elizabeth L ChouDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass.
Christian L Lino CardenasCardiovascular Research Center, Massachusetts General Hospital, Boston, Mass.
Mark ChaffinCardiovascular Disease Initiative, The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, Mass.
Alessandro D ArduiniCardiovascular Disease Initiative, The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, Mass.
Dejan JuricCancer Center, Massachusetts General Hospital, Boston, Mass.
James R StoneDepartment of Pathology, Massachusetts General Hospital, Boston, Mass.
Glenn M LaMuragliaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass.
Matthew J EagletonDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass.
Mark F ConradDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass.
Eric M IsselbacherDivision of Cardiology, Massachusetts General Hospital, Boston, Mass.
Patrick T EllinorCardiovascular Research Center, Massachusetts General Hospital, Boston, Mass.
Mark E LindsayCardiovascular Research Center, Massachusetts General Hospital, Boston, Mass.
Harvard University · USMassachusetts General Hospital · USBroad Institute · US

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
The Role of HDAC9/MITR in the Pathogenesis of Thoracic Aortic Aneurysm (TAA)R01HL130113 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LINDSAY, MARK E · 2016 to 2020
$2.0M
Mentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2M
Targeting Chronic Senescence to Restore Tissue Homeostasis in Myhre syndromeR21AR080778 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI LINDSAY, MARK E, MOU, HONGMEI · 2022 to 2023
$386k
NHLBI NIH HHS K24 HL105780NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL130113NHLBI NIH HHS T32 HL007208NIAMS NIH HHS R21 AR080778
6 · The paper itself

Abstract

Carotid plaque instability contributes to large vessel ischemic stroke. Although vascular smooth muscle cells (VSMCs) affect atherosclerotic growth and instability, no treatments aimed at improving VSMC function are available. Large genetic studies investigating atherosclerosis and carotid disease in relation to the risk of stroke have implicated polymorphisms at the

Indexed as

AtherosclerosisCarotidSingle cell sequencingVascular smooth muscle cells

Identifiers

PMID35128489
PMCPMC8802874
OpenAlexW4200613928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.