Evidence map›Paper›PMID 35128468›Full record

ArticleCurrent research in physiology2022

Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment.

Dharendra Thapa, Bingxian Xie, Bellina A S Mushala, Manling Zhang, Janet R Manning, Paramesha Bugga, Michael W Stoner, Michael J Jurczak, Iain Scott

Open access · goldAbstract read
In one paragraph

Article in Current research in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Role of adropin in arterial stiffening associated with obesity and type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  6. Adropin's Role in Energy Homeostasis and Metabolic Disorders.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dharendra ThapaDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Bingxian XieDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Bellina A S MushalaDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Manling ZhangDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Janet R ManningDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Paramesha BuggaDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Michael W StonerDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
Michael J JurczakCenter for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Iain ScottDivision of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

Novel strategies to resolve metabolic defects in the diabetic heartR01HL147861 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCOTT, IAIN · 2020 to 2024
$2.4M
Predoctoral Training in Pharmacological Sciences (Resubmission)T32GM133332 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tija C. Jacob, Francisco Jose Schopfer · 2020 to 2026
$1.8M
The Role of GCN5L1 Mediated Mitochondria to Nucleus Retrograde Cardiac Metabolism Reprogramming in Exercise and Heart FailureK08HL157616 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHANG, MANLING · 2021 to 2025
$802k
Investigating the novel role of acetylation in cardiac mitochondrial bioenergetics and function in the aging heartR00HL146905 · NHLBI · WEST VIRGINIA UNIVERSITY · PI THAPA, DHARENDRA · 2021 to 2023
$747k
Investigating the novel role of acetylation in cardiac mitochondrial bioenergetics and function in the aging heartK99HL146905 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THAPA, DHARENDRA · 2020 to 2021
$346k
NHLBI NIH HHS K08 HL157616NHLBI NIH HHS K99 HL146905NHLBI NIH HHS R00 HL146905NHLBI NIH HHS R01 HL147861NIGMS NIH HHS T32 GM133332
6 · The paper itself

Abstract

Previous studies have shown that treatment with recombinant adropin, a circulating peptide secreted by the liver and brain, restores glucose utilization in the hearts of diet-induced obese mice. This restoration of fuel substrate flexibility, which is lost in obese and diabetic animals, has the potential to improve contractile function in the diabetic heart. Using an

Indexed as

AdropinCardiac functionContractilityHigh fat dietInsulinMice

Identifiers

PMID35128468
PMCPMC8803554
OpenAlexW4226003968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.