ArticleReproduction & fertility2021
Analysing culture methods of frozen human ovarian tissue to improve follicle survival.
Article in Reproduction & fertility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Transcriptomic insights into ovine ovarian response to extended in vitro culture and cryopreservation.Journal of assisted reproduction and genetics · 2026Article
- Patient-specific in vitro follicle development in response to ovarian freezing and culture.Reproduction & fertility · 2026Article
- Three-dimensional visualisation of human ovarian follicles using a whole-mount immunolabelling and optical tissue clearing method.Reproduction & fertility · 2025Article
- Short-Term In Vitro Culture of Human Ovarian Tissue: A Comparative Study of Serum Supplementation for Primordial Follicle Survival.Life (Basel, Switzerland) · 2025Article
- What do women and rhinos have in common?F&S reports · 2025Article
- Advances in ovarian follicle culture systems: exploring the interplay between cells, matrix, and ovarian architecture.Animal reproduction · 2025Article
- A spotlight on factors influencing the in vitro folliculogenesis of isolated preantral follicles.Journal of assisted reproduction and genetics · 2024Article
- Assessment of molecular and morphological dynamics during long-timeFrontiers in endocrinology · 2024Article
- Effects of chemicalHuman reproduction open · 2024Article
- Method of Isolation and In Vitro Culture of Primordial Follicles in Bovine Animal Model.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests.Communications biology · 2023Article
- Co-culture of human cryopreserved fragmented ovarian tissue with theca progenitor cells derived from theca stem cells.Journal of assisted reproduction and genetics · 2023Article
- RNA Transcripts in Human Ovarian Cells: Two-Time Cryopreservation Does Not Affect Developmental Potential.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
LAY SUMMARY: Ovaries contain a large number of follicles, each containing an immature egg and other important cells. Cancer treatments can lead to long-lasting negative side effects to the ovaries including the destruction of follicles, resulting in infertility. One strategy to preserve fertility is freezing of ovaries or ovarian tissue in girls and women undergoing cancer treatment. The long-term aim is to thaw and grow their ovarian tissue in the laboratory to obtain mature eggs, which can then be fertilised. In this study, we compared six different methods of growing previously frozen human ovarian tissue in order to best support follicle growth and health. We found that using the lowest amount of αMEM medium (a specific type of nutrient-rich growth solution) resulted in the highest proportion of healthy follicles. Improving the methods used to grow ovarian tissue, particularly frozen tissue, is important for future fertility preservation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.