Evidence map›Paper›PMID 35128382›Full record

ArticleInternational journal of pharmaceutics: X2022

Diarmaid J Murphy, Yahya H Dallal Bashi, Clare F McCoy, Peter Boyd, Leeanne Brown, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Diarmaid J MurphySchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
Yahya H Dallal BashiSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
Clare F McCoySchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
Peter BoydSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.
Leeanne BrownElkem Silicones, Two Tower Centre Boulevard, Suite 1802, East Brunswick, NJ 08816, USA.
François MartinElkem Silicones, Two Tower Centre Boulevard, Suite 1802, East Brunswick, NJ 08816, USA.
Nicole McMullenElkem Silicones, Two Tower Centre Boulevard, Suite 1802, East Brunswick, NJ 08816, USA.
Kyle KleinbeckInternational Partnership for Microbicides, Silver Spring, MD 2910, USA.
Bindi DangiInternational Partnership for Microbicides, Silver Spring, MD 2910, USA.
Patrick SpenceInternational Partnership for Microbicides, Silver Spring, MD 2910, USA.
Bashir HansrajInternational Partnership for Microbicides, Silver Spring, MD 2910, USA.
Bríd DevlinInternational Partnership for Microbicides, Silver Spring, MD 2910, USA.
R Karl MalcolmSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception. During initial development, issues arose due to reaction between the ethynyl group in the levonorgestrel molecule and the hydride-functionalised polydimethylsiloxane components in the silicone elastomer formulation. This unwanted reaction occurred both during and to a lesser extent after ring manufacture, impacting the curing process, the mechanical properties of the ring, and the

Indexed as

HIV microbicideHormonal contraceptionIn vitro drug releaseMechanical propertiesMultipurpose prevention technology (MPT)Silicone elastomer

Identifiers

PMID35128382
PMCPMC8804184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.