Evidence map›Paper›PMID 35128361›Full record

ArticleEClinicalMedicine2022

Reproductive outcomes and reproductive tract microbiota shift in women with moderate-to-severe intrauterine adhesions following 30-day post-hysteroscopic placement of balloon stents or intrauterine contraceptive devices: A randomized controlled trial.

Yue Wang, Yu Zhao, Yuan Ge, Jin Cen, Yun Liao, Gufeng Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yue WangDepartment of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, China, 310006.
Yu ZhaoDepartment of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, China, 310006.
Yuan GeDepartment of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, China, 310006.
Jin CenDepartment of Gynecology, Ninghai Maternal and Child Health Hospital, 365 Xinghaizhong Road, Ninghai, China, 315600.
Yun LiaoDepartment of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, China, 310006.
Gufeng XuDepartment of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, China, 310006.
Women's Hospital, School of Medicine, Zhejiang University · CNWeihai Maternal and Child Health Hospital · CNBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntrauterine adhesions (IUA) develop in up to 20% of women with a history of abortion. After hysteroscopic adhesiolysis, balloon stents are usually placed for seven days to prevent recurrence. The efficacy of prolonged use (30 days) of balloon stents has not been determined.

methodsThe trial was conducted from June 2019 to March 2021. Ninety-one patients who underwent hysteroscopic adhesiolysis for moderate or severe IUA were randomized to receive a 30-day placement of a balloon stent (n = 44) or an intrauterine device (IUD) (n = 47). The primary outcomes were the ongoing pregnancy and miscarriage rates assessed at 15-19 months. The secondary outcomes were the recurrence of IUA and the American Fertility Society (AFS) intrauterine adhesion scores at the first and second hysteroscopies, the diagnosis of new chronic endometritis at the second-look hysteroscopy, and the vaginal/uterine microbiome assessed using 16S rRNA sequencing. The trial was registered at Chinese Clinical Trial Registry (ChiCTR1900023306).

findingsThe ongoing pregnancy rates (balloon 56·4% versus IUD 57·1%) and miscarriage rates (balloon 10·3% versus IUD 22·9%) were not significantly different between the groups. No differences in the recurrence of IUA, reduction of AFS scores, or new endometritis rates were detected. The bacterial load in the uterus and vagina increased in the IUD group but not in the balloon group.

interpretationBalloon placement has a similar effect on ongoing pregnancy rates as intrauterine device (IUD) placement. Patients who underwent balloon placement had a lower miscarriage rate, although the difference was not significant. There were no differences in the recurrence rate of IUA, reduction of American Fertility Society scores, or rate of new chronic endometritis. The balloon stent has less effects on the uterine microbiota.

fundingNational Natural Science Foundation of China (81802593).

Indexed as

balloonhysteroscopic adhesiolysisintrauterine adhesionsintrauterine contraception devicemicrobiota

Identifiers

PMID35128361
PMCPMC8808160
OpenAlexW4206426876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.