Evidence map›Paper›PMID 35128351›Full record

ArticleiScience2022

Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in

Cherng-Shyang Chang, Wen-Hsuan Yu, Chang-Chao Su, Jhen-Wei Ruan, Chiao-Mei Lin, Chih-Ting Huang, Yi-Ting Tsai, I-Jung Lin, Chao-Yang Lai, Tsung-Hsien Chuang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Cherng-Shyang ChangImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Wen-Hsuan YuGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan.
Chang-Chao SuDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 60002, Taiwan.
Jhen-Wei RuanDepartment of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan.
Chiao-Mei LinImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Chih-Ting HuangImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Yi-Ting TsaiImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
I-Jung LinImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Chao-Yang LaiImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Tsung-Hsien ChuangImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Wen-Jye LinImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Tse-Hua TanImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
Hsuan-Cheng HuangInstitute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Hsueh-Fen JuanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan.
Cheng-Yuan KaoImmunology Research Center, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan.
National Health Research Institutes · TWNational Taiwan University · TWAsia University · TWChia-Yi Christian Hospital · TWNational Cheng Kung University · TWNational Chung Hsing University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-cell RNA sequencing (scRNA-seq) approach can broadly and specifically evaluate the individual cells with minimum detection bias. To explore the individual compositional and transcriptional alteration of intestinal leukocytes in the Dual Specificity Phosphatase six knockout (D6KO) mice, we performed a scRNA-seq followed by the cell type annotation based on ImmGen database. Composition assessments found that D6KO-derived intestinal leukocytes tend to stay inactivate or immature status. The enrichment analysis showed that D6KO-derived intestinal leukocytes are less sensitive to microbes. The

Indexed as

Biological sciencesImmunologyTranscriptomics

Identifiers

PMID35128351
PMCPMC8800014
OpenAlexW4206240743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.