Evidence map›Paper›PMID 35128233›Full record

ArticleACS omega2022

Phage Display-Derived Peptide for the Specific Binding of SARS-CoV-2.

Fan Yang, Li Liu, Pierre Fernand Neuenschwander, Steven Idell, Ramakrishna Vankayalapati, Krishan Gopal Jain, Ke Du, Honglong Ji, Guohua Yi

Abstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Phage Display as a Promising Platform for Peptide Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Isolation of Peptide Ligands for the HIV Capsid Protein p24 by Phage-Display.International journal of peptide research and therapeutics · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fan YangDepartment of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.
Li LiuDepartment of Microsystems Engineering, Rochester Institute of Technology, Rochester, New York 14623-5603, United States.
Pierre Fernand NeuenschwanderDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.
Steven IdellDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.
Ramakrishna VankayalapatiDepartment of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.
Krishan Gopal JainDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.
Ke DuDepartment of Microsystems Engineering, Rochester Institute of Technology, Rochester, New York 14623-5603, United States.
Honglong JiDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.
Guohua YiDepartment of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708-3154, United States.ORCID https://orcid.org/0000-0001-8075-5478

Funding

NOVEL PARACRINE MECHANISMS FOR CELL-BASED THERAPY OF INJURED LUNGSR01HL134828 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI JI, HONG-LONG · 2017 to 2025
$3.4M
Novel CRISPR-Cas9 protein delivery to T cells in vivo by targeting CD7UG3AI150550 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI YI, GUOHUA · 2019 to 2021
$2.1M
NIAID NIH HHS UG3 AI150550
6 · The paper itself

Abstract

Beginning from the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic swept all over the world and is still afflicting the whole global population. Given that the vaccine-manufacturing ability is limited and the virus can evolve quickly, vaccination alone may not be able to end the pandemic, thus developing fast and accurate diagnoses and effective therapeutics will always be unmet needs. Phage display peptide library has been used in screening antigen-specific peptides for the invention of novel mimic receptors/ligands. Here, we report that a 12-mer phage display peptide library has been screened against the SARS-CoV-2 receptor-binding domain (RBD), and five of the screened peptides show binding ability with the RBD protein by the enzyme-linked immune sorbent assay. The surface plasmon resonance assay further demonstrates that peptide no. 1 can specifically bind to SARS-CoV-2 RBD with a binding affinity constant (

Identifiers

PMID35128233
PMCPMC8751651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.