Evidence map›Paper›PMID 35128159›Full record

ArticleAmerican journal of ophthalmology case reports2022

Familial exudative vitreoretinopathy associated with retinal astrocytic hamartoma.

Jason Fan, Nandini Venkateswaran, Kenneth C Fan, Linda A Cernichiaro, Catherin I Negron, Craig A McKeown, Audina M Berrocal

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jason FanBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Nandini VenkateswaranBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Kenneth C FanBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Linda A CernichiaroBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Catherin I NegronBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Craig A McKeownBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
Audina M BerrocalBascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
University of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the first case of retinal astrocytic hamartoma (RAH) arising in the setting of Familial Exudative Vitreoretinopathy (FEVR). OBSERVATIONS: An otherwise healthy 3-month-old male was clinically diagnosed with Familial Exudative Vitreoretinopathy, with subsequent confirmation of a Frizzled-4 nonsense gene mutation. He was treated with multiple rounds of laser photocoagulation after demonstrated peripheral non-perfusion on fluorescein angiography. At 4 years of age, he was noted to have a solitary retinal astrocytic hamartoma in an area of anterior retinal traction which remains under observation. CONCLUSIONS AND IMPORTANCE: This case describes the first reported instance of a retinal astrocytic hamartoma arising in the setting of FEVR. Multiple factors may have contributed to the formation of this benign tumor, including retinal dysgenesis, genetic background, or even laser photocoagulation. More case reports and/or molecular studies are required to further clarify the potential role of these insults in the pathogenesis of RAH.

Indexed as

Familial exudative vitreoretinopathy (FEVR)FEVR, Familial Exudative VitreoretinopathyFrizzled-4 (FZD4)RAH, Retinal Astrocytic HamartomaRetinal astrocytic hamartoma (RAH)

Identifiers

PMID35128159
PMCPMC8807981
OpenAlexW4210528734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.