Evidence map›Paper›PMID 35128155›Full record

ArticleAmerican journal of ophthalmology case reports2022

Very late onset LASIK flap Acremonium fungal keratitis confirmed by metagenomic deep sequencing.

Miles F Greenwald, Travis K Redd, Thuy Doan, Stephen D McLeod, Gerami D Seitzman

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Post-laser refractive surgery keratitis: A concise narrative review.The Journal of international medical research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Miles F GreenwaldDepartment of Ophthalmology, Kellogg Eye Center, University of Michigan Medical Center, 1000 Wall St, Ann Arbor, MI, 48105, United States.
Travis K ReddDepartment of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, 515 SW Campus Dr, Portland, OR, 97239, United States.
Thuy DoanFrancis I. Proctor Foundation, University of California San Francisco, 490 Illinois St, San Francisco, CA, 94158, United States.
Stephen D McLeodFrancis I. Proctor Foundation, University of California San Francisco, 490 Illinois St, San Francisco, CA, 94158, United States.
Gerami D SeitzmanFrancis I. Proctor Foundation, University of California San Francisco, 490 Illinois St, San Francisco, CA, 94158, United States.
University of California, San Francisco · USOregon Health & Science University · USUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe a unique case of LASIK flap fungal keratitis confirmed by next generation sequencing. OBSERVATIONS: A 56-year-old female presented with refractory keratitis involving her LASIK flap 21 years after surgery. Confocal was positive for filamentous structures. The patient underwent immediate flap amputation followed by topical antifungal treatment. Corneal culture was positive for

conclusionsMetagenomic deep sequencing is a novel diagnostic tool that is increasingly being utilized for diagnosis of refractory keratitis. This case demonstrates the diagnostic potential of deep sequencing for identifying post-LASIK keratitis and reinforces the utility of LASIK flap amputation in the setting of tectonic flap instability due to keratolysis. IMPORTANCE: This case highlights several important clinical points for treating LASIK flap keratitis and highlights the emerging role metagenomic sequencing has in the diagnosis of infectious keratitis. This is first known case using next generation sequencing to diagnose a post-LASIK infectious keratitis.

Indexed as

LASIK Flap amputationLASIK Fungal keratitisMetagenomic deep sequencing

Identifiers

PMID35128155
PMCPMC8807967
OpenAlexW4205558285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.