Evidence map›Paper›PMID 35128137›Full record

ArticleJournal of the anus, rectum and colon2022

A Trial Protocol of Precision Medicine for Patients with RAS Wild Metastatic Colorectal Cancer Using Liquid Biopsy (RAS-liquid Study): A Prospective, Multicenter Observational Study.

Akihisa Matsuda, Takeshi Yamada, Takao Takahashi, Keiji Hirata, Takeshi Nagasaka, Kei Ishimaru, Kazuhiro Sakamoto, Keiji Koda, Toshiaki Ishikawa, Hideyuki Ishida and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the anus, rectum and colon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 1 country.

Akihisa MatsudaDepartment of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Takeshi YamadaDepartment of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Takao TakahashiDepartment of Surgical Oncology, Graduate School of Medicine, Gifu University, Gifu, Japan.
Keiji HirataDepartment of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
Takeshi NagasakaDepartment of Clinical Oncology, Kawasaki Medical School and Hospital, Okayama, Japan.
Kei IshimaruDepartment of Minimally Invasive Gastroenterology, Ehime University Graduate School of Medicine, Ehime, Japan.
Kazuhiro SakamotoDepartment of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Keiji KodaDepartment of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
Toshiaki IshikawaDepartment of Specialized Surgeries, Medical Research Institute, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Kenji MatsudaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Hidekazu KuramochiDepartment of Chemotherapy, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
Yoichiro YoshidaDepartment of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Hiromichi SonodaDepartment of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Hiroshi YoshidaDepartment of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Nippon Medical School · JPEhime University · JPFukuoka University · JPGifu University · JPJuntendo University · JPKawasaki Medical School Hospital · JPSaitama Medical University · JPTeikyo University Chiba Medical Center · JPTokyo Medical and Dental University · JPTokyo Women's Medical University · JPUniversity of Occupational and Environmental Health Japan · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnti-epidermal growth factor receptor (EGFR) therapy has been identified to prolong the survival of metastatic colorectal cancer (mCRC) patients without METHODS/

designThis study is a prospective, multicenter, observational study of mCRC patients with wild-type tissue DISCUSSION: This study will clarify the predictive value of baseline

Indexed as

anti-EGFR antibodycell-free DNAcirculating tumor DNAliquid biopsymetastatic colorectal cancer

Identifiers

PMID35128137
PMCPMC8801244
OpenAlexW4210808495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.