ReviewClinical and translational radiation oncology2022
Dose-volume predictors of post-radiation primary hypothyroidism in head and neck cancer: A systematic review.
Review in Clinical and translational radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of Updated Level IVa Nodal Delineation on Thyroid Dose and Hypothyroidism Risk in Nasopharyngeal Carcinoma.Advances in radiation oncology · 2026Article
- Thyroid function and ultrasound surveillance in childhood cancer survivors (CCS): a position paper of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).Journal of endocrinological investigation · 2026Review
- Thyroid dose guidance in elective supraclavicular breast radiotherapy: a national survey of practice patterns in Switzerland.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Comparative study between PET-CT simulation and CT for head and neck cancer treatment and their potential effect on the thyroid gland: a prospective comparative study.Radiation oncology (London, England) · 2026Article
- Patterns of regional recurrences after treatment of nasopharyngeal carcinoma.Radiation oncology (London, England) · 2026Article
- Positioning accuracy and dosimetric evaluation of customized immobilization for FBCT guided VMAT in nasopharyngeal carcinoma.Scientific reports · 2025Article
- Occupational Radiation Exposure and Thyroid Nodules in Healthcare Workers: A Review.International journal of molecular sciences · 2025Review
- Clinical and Dosimetric Predictors of Early Onset Postradiation Hypothyroidism in Patients with Head and Neck Malignancies: A Logistic Regression Analysis.Oncology and therapy · 2025Article
- Predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients using a deep learning model.Clinical and translational radiation oncology · 2025Article
- Evaluation of a comprehensive set of normal tissue complication probability models for patients with head and neck cancer in an international cohort.Oral oncology · 2025Article
- A subregional prediction model for radiation-induced hypothyroidism.BMC medical imaging · 2025Article
- Thyroid-sparing volume-modulated arc therapy in patients with non-distant metastatic nasopharyngeal carcinoma: a feasibility study.Frontiers in oncology · 2025Article
- Normal tissue complication probability models of hypothyroidism after radiotherapy for breast cancer.Clinical and translational radiation oncology · 2024Article
- Analysis of correlative risk factors for radiation-induced hypothyroidism in head and neck tumors.BMC cancer · 2024Article
- Improved prediction of radiation-induced hypothyroidism in nasopharyngeal carcinoma using pre-treatment CT radiomics.Scientific reports · 2023Article
- Impact of Thyroid Dose on Radiation-induced Hypothyroidism in Early Glottic Cancer Patients Undergoing Volumetric Modulated Arc Therapy.In vivo (Athens, Greece)Article
- Association Between Thyroid Radiation Dose and Hypothyroidism in Breast Cancer Patients Undergoing Volumetric Modulated Arc Therapy for Regional Nodal Irradiation.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThis systematic review aims to identify radiation dose-volume predictors of primary hypothyroidism after radiotherapy in patients with head and neck cancer (HNC). MATERIALS AND
methodsWe performed a systematic literature search of Medline, EMBASE and Web of Science from database inception to July 1, 2021 for articles that discuss radiation dose-volume predictors of post-radiation primary hypothyroidism in patients with HNC. Data on the incidence, clinical risk factors and radiation dose-volume parameters were extracted. A meta-analysis was performed using the random-effects model to estimate the pooled odds ratio (OR) of thyroid volume as a predictor of the risk of post-radiation hypothyroidism, adjusted for thyroid radiation dosimetry.
resultsOur search identified 29 observational studies involving 4,530 patients. With median follow-up durations ranging from 1.0 to 5.3 years, the average crude incidence of post-radiation primary hypothyroidism was 41.4 % (range, 10 %-57 %). Multiple radiation dose-volume parameters were associated with post-radiation primary hypothyroidism, including the thyroid mean dose (Dmean), minimum dose, V25, V30, V35, V45, V50, V30-60, VS45 and VS60. Thyroid Dmean and V50 were the most frequently proposed dosimetric predictors. The pooled adjusted OR of thyroid volume on the risk of post-radiation primary hypothyroidism was 0.89 (95 % confidence interval, 0.85-0.93; p < 0.001) per 1 cc increment.
conclusionPost-radiation primary hypothyroidism is a common late complication after radiotherapy for HNC. Minimizing inadvertent exposure of the thyroid gland to radiation is crucial to prevent this late complication. Radiation dose-volume constraints individualized for thyroid volume should be considered in HNC radiotherapy planning.
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