Evidence map›Paper›PMID 35128081›Full record

ArticleBiochemistry and biophysics reports2022

Thiol antioxidants protect human lens epithelial (HLE B-3) cells against

Annalise Pfaff, Anna Chernatynskaya, Hannah Vineyard, Nuran Ercal

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Annalise PfaffDepartment of Chemistry, Missouri University of Science & Technology, 104 Schrenk Hall, 400 W. 11th Street, Rolla, MO, 65409, USA.
Anna ChernatynskayaDepartment of Chemistry, Missouri University of Science & Technology, 104 Schrenk Hall, 400 W. 11th Street, Rolla, MO, 65409, USA.
Hannah VineyardDepartment of Chemistry, Missouri University of Science & Technology, 104 Schrenk Hall, 400 W. 11th Street, Rolla, MO, 65409, USA.
Nuran ErcalDepartment of Chemistry, Missouri University of Science & Technology, 104 Schrenk Hall, 400 W. 11th Street, Rolla, MO, 65409, USA.
Missouri University of Science and Technology · US

Funding

Enhancing ocular uptake of thiol antioxidants with nanodiamondsR15EY029813 · NEI · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · PI ERCAL, NURAN, MOCHALIN, VADYM · 2019 to 2019
$388k
NEI NIH HHS R15 EY029813
6 · The paper itself

Abstract

Oxidative damage to lens epithelial cells plays an important role in the development of age-related cataract, and the health of the lens has important implications for overall ocular health. As a result, there is a need for effective therapeutic agents that prevent oxidative damage to the lens. Thiol antioxidants such as tiopronin or

Indexed as

7-AAD, 7-aminoactinomycin DAntioxidantATCC, American Type Culture CollectionCarboxy-H2DCFDA, 6-carboxy-2′,7′-dichlorodihydrofluorescein diacetateCataractEMEM, Eagle's minimum essential mediumFBS, fetal bovine serumFDA, United States Food and Drug AdministrationGlutathioneGSH, glutathioneGSSG, glutathione disulfideH2O2, hydrogen peroxideHLE B-3, human (eye) lens epithelial cell line B-3LensMPG, N-(2-mercaptopropionyl)glycineMTT, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)NACA, N-acetylcysteine amideNAC, N-acetylcysteineOH•, hydroxyl radicalOxidative stressPBS, phosphate-buffered salineROS, reactive oxygen speciestBHP, tert-butyl hydroperoxideThiol

Identifiers

PMID35128081
PMCPMC8808075
OpenAlexW4210584853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.