Evidence map›Paper›PMID 35127970›Full record

ArticleInternational journal of particle therapy2022

Bone Marrow Suppression during Postoperative Radiation for Bladder Cancer and Comparative Benefit of Proton Therapy-Phase 2 Trial Secondary Analysis.

Robert H Press, Joseph W Shelton, Chao Zhang, Quang Dang, Sibo Tian, Timothy Shu, Crystal S Seldon, Shaakir Hasan, Ashesh B Jani, Jun Zhou and 1 more

Open access · diamondAbstract read
In one paragraph

Article in International journal of particle therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Robert H PressNew York Proton Center, New York, NY, USA.
Joseph W SheltonDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Chao ZhangBiostatistics Core of Department Pediatrics, Emory University, Atlanta, GA, USA.
Quang DangDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Sibo TianDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Timothy ShuDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Crystal S SeldonDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Shaakir HasanNew York Proton Center, New York, NY, USA.
Ashesh B JaniDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Jun ZhouDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Mark W McDonaldDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Emory University · USNew York Proton Center · USUniversity of Miami · US

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
NCI NIH HHS P30 CA138292
6 · The paper itself

Abstract

purposeFor patients with high-risk bladder cancer (pT3 MATERIALS AND

methodsAll enrolled patients were retrospectively analyzed after pelvic radiation per protocol with 50.4 to 55.8 Gy in 28 to 31 fractions. Comparative PBT plans were generated using pencil-beam scanning and a 3-beam multifield optimization technique. Changes in hematologic nadirs were assessed using paired

resultsEighteen patients with a median age of 70 were analyzed. Mean cell count values after radiation therapy decreased compared with preradiation therapy values for white blood cells (WBCs), absolute neutrophil count (ANC), absolute lymphocyte count (all

conclusionIncreased PBM mean dose and V20 to V40 were associated with lower hematologic nadirs. PBT plans reduced PBM dose and may be a valuable strategy to reduce the risk of hematologic toxicity in these patients.

Indexed as

bone marrow suppressioncystectomylymphopeniaproton therapyurinary bladder neoplasms

Identifiers

PMID35127970
PMCPMC8768898
OpenAlexW3178803599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.