Evidence map›Paper›PMID 35127864›Full record

ArticleFrontiers in cardiovascular medicine2021

Proinflammatory Matrix Metalloproteinase-1 Associates With Mitral Valve Leaflet Disruption Following Percutaneous Mitral Valvuloplasty.

Livia S A Passos, Dakota Becker-Greene, Renato Braulio, Thanh-Dat Le, Cláudio L Gelape, Luís Felipe R de Almeida, Divino Pedro A Rocha, Carlos Augusto P Gomes, William A M Esteves, Luiz G Passaglia and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The role of monocytes in thrombotic diseases: a review.Frontiers in cardiovascular medicine · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Livia S A PassosCenter for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Dakota Becker-GreeneCenter for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Renato BraulioSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Thanh-Dat LeCenter for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Cláudio L GelapeSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Luís Felipe R de AlmeidaSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Divino Pedro A RochaSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Carlos Augusto P GomesSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
William A M EstevesSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Luiz G PassagliaSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jacob P Dal-BiancoCardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Robert A LevineCardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Masanori AikawaCenter for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Judy HungCardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Walderez O DutraDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Maria Carmo P NunesSchool of Medicine, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Elena AikawaCenter for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Universidade Federal de Minas Gerais · BRHospital das Clínicas da Universidade Federal de Minas Gerais · BRHarvard University · USBrigham and Women's Hospital · USSechenov University · RUMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitral regurgitation (MR) is a major complication of the percutaneous mitral valvuloplasty (PMV). Despite high technical expertise and cumulative experience with the procedure, the incidence rate of severe MR has not decreased. Although some of MR can be anticipated by echocardiographic analysis; leaflet tearing, which leads to the most dreaded type of MR, remains unpredictable. Irregular valvular collagen remodeling is likely to compromise tissue architecture and increase the tearing risk during PMV balloon inflation. In this study, we evaluated histological and molecular characteristics of excised mitral valves from patients with rheumatic mitral stenosis (MS) who underwent emergency surgery after PMV due to severe MR caused by leaflet tear. Those findings were compared with patients who underwent elective mitral valve replacement surgery owing to severe MS, in whom PMV was not indicated.

Indexed as

collageninflammationMMP-1percutaneous mitral valvuloplastyrheumatic heart disease

Identifiers

PMID35127864
PMCPMC8811173
OpenAlexW4205103034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.