ArticleFrontiers in medicine2021
Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort.
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Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 19 citations in OpenAlex.
- Efficacy and safety of Suhuang Zhike capsule for cough variant asthma: a multicenter, single-arm, open-label phase IV real-world clinical trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- Cynaroside reduces neutrophil extracellular trap formation and disease severity in a mouse model of asthma by inhibiting the COX-2/TNF-alpha/NF-kB axis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Difference of breath sound spectrum between healthy children and children with cough variant asthma.BMC pediatrics · 2026Article
- Pulmonary function and risk factors in pediatric chest tightness variant asthma: a case-control study.Frontiers in pediatrics · 2026Article
- Global trends and hotspots in research of cough variant asthma: a bibliometric and visual analysis from 2004 to 2024.Journal of thoracic disease · 2025Article
- Associations of mucus plugging, small airway dysfunction, and airway wall thickening in cough-variant asthma versus asthma.European journal of medical research · 2025Article
- Identification of two distinct molecular endotypes in cough-variant asthma based on sputum transcriptomics and clinical pathophysiological features.ERJ open research · 2025Article
- Cough-Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology.The journal of allergy and clinical immunology. In practice · 2025Review
- Development and validation of a nomogram for predicting cough variant asthma diagnosis.BMC pulmonary medicine · 2025Article
- The Value of Body Plethysmography (sGaw) in the Assessment of Airway Hyperreactivity in Cough Variant Asthma.Journal of clinical medicine · 2024Article
- Retrospective, observational study of different medication regimens and outcome in children with cough variant asthma.Immunity, inflammation and disease · 2024Observational
- Article
- The Effects of Budesonide Inhalation Treatment on the Expression Levels of Serum IL-6, TGF-β1, and IgE and Pulmonary Function in Patients with Cough Variant Asthma and an Evaluation of Treatment Efficacy.International journal of general medicine · 2024Article
- Study on the Relationship Between Bronchoalveolar Lavage Fluid Cell Count, Th1/Th2 Cytokines and Pulmonary Function in Patients with Cough Variant Asthma.Journal of asthma and allergy · 2022Article
- Mechanism of Action of Yin Nourishing and Heat Clearing Prescription in Treating Cough Variant Asthma Based on Network Pharmacology and Molecular Docking Verification.Computational and mathematical methods in medicine · 2022Article
- Phenotypes and endotypes of cough in asthma.Therapeutic advances in respiratory diseaseReview
- Development of a clinical prediction model for cough variant asthma.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
30 authors at 20 institutions in 2 countries.
Kefang LaiDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenzhi ZhanDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Feng WuDepartment of Pulmonary and Critical Care Medicine, Huizhou The Third People's Hospital, Huizhou, China.
Yunhui ZhangDepartment of Pulmonary and Critical Care Medicine, The First People's Hospital of Yunnan Province, Kunming, China.
Lin LinDepartment of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.
Wen LiDepartment of Pulmonary and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Fang YiDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ziyu JiangDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yuanrong DaiDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Suyun LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Jiangtao LinDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.
Yadong YuanDepartment of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Yong JiangDepartment of Respiratory and Critical Care Medicine, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China.
Chen QiuDepartment of Respiratory and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen, China.
Limin ZhaoDepartment of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Meihua ChenDepartment of Pulmonary and Critical Care Medicine, Songshan Lake Central Hospital of Dongguan City, The Third People's Hospital of Dongguan City, Dongguan, China.
Zhongmin QiuDepartment of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.
Hu LiDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ruchong ChenDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wei LuoDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jiaxing XieDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chunxing GuoDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Mei JiangDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaohong YangDepartment of Respiratory and Critical Care Medicine, Xinjiang Interstitial Lung Disease Clinical Medicine Research Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Guochao ShiDepartment of Pulmonary and Critical Care Medicine, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Beijing, China.
Dejun SunDepartment of Pulmonary and Critical Care Medicine, The Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.
Rongchang ChenDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Foundation NHS Trust, London, United Kingdom.
Huahao ShenDepartment of Pulmonary and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Nanshan ZhongDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNSecond Affiliated Hospital of Zhejiang University · CNState Key Laboratory of Respiratory Disease · CNChina-Japan Friendship Hospital · CNDongguan People’s Hospital · CNFirst Affiliated Hospital of Henan University · CNFirst People's Hospital of Yunnan Province · CNGuangzhou University of Chinese Medicine · CNHebei Medical University · CNHenan Provincial People's Hospital · CNHuizhou Central People's Hospital · CNInner Mongolia People's Hospital · CNJinan University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNRoyal Brompton & Harefield NHS Foundation Trust · GBShanghai Jiao Tong University · CNShenzhen Pingle Orthopedic Hospital · CNSouthern University of Science and Technology · CNTongji University · CN
Funding
Medical Research Council MR/T010371/1
Abstract
backgroundThe AtyPical Asthma in China (APAC) cohort is a multi-center prospective, observational cohort set-up to investigate the clinical, pathophysiological features, prognosis, and mechanisms of cough variant asthma (CVA).
objectivesTo present the characteristics of newly physician-diagnosed adults with CVA ( METHODS AND MAIN
resultsCVA subjects showed a higher proportion of female (67.1 vs. 55.3%,
conclusionCough variant asthma is distinctive from classic asthma in regard to clinical features, lung function, and airway inflammation. Quality of life is badly impaired as well in spite of better asthma control scores.
Indexed as
airway inflammationbronchial hyperresponsivenessclassic asthma (CA)coughcough variant asthma (CVA)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.