Evidence map›Paper›PMID 35127742›Full record

ArticleFrontiers in medicine2021

Immune Checkpoint Gene Expression Profiling Identifies Programmed Cell Death Ligand-1 Centered Immunologic Subtypes of Oral and Squamous Cell Carcinoma With Favorable Survival.

Yang Yu, Huiwen Tang, Debora Franceschi, Prabhakar Mujagond, Aneesha Acharya, Yupei Deng, Bernd Lethaus, Vuk Savkovic, Rüdiger Zimmerer, Dirk Ziebolz and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Yang YuDepartment of Stomatology, Qunli Branch, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Huiwen TangDepartment of Stomatology, Qunli Branch, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Debora FranceschiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Prabhakar MujagondRegional Centre for Biotechnology, 3rd Milestone Gurgaon-Faridabad Expressway, Faridabad, India.
Aneesha AcharyaDr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India.
Yupei DengLaboratory of Molecular Cell Biology, China Tibetology Research Center, Beijing Tibetan Hospital, Beijing, China.
Bernd LethausDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Leipzig, Germany.
Vuk SavkovicDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Leipzig, Germany.
Rüdiger ZimmererDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Leipzig, Germany.
Dirk ZiebolzDepartment of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Simin LiStomatological Hospital, Southern Medical University, Guangzhou, China.
Gerhard SchmalzDepartment of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
University Hospital Leipzig · DELeipzig University · DEChina Tibetology Research Center · CNDr D Y Patil Dental College & Hospital · INFirst Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNRegional Centre for Biotechnology · INSouthern Medical University · CNUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to identify the programmed death ligand-1 (PDL1, also termed as CD274) and its positively correlated immune checkpoint genes (ICGs) and to determine the immune subtypes of CD274-centered ICG combinations in oral and squamous cell carcinoma (OSCC). MATERIALS AND

methodsFirstly, the 95 ICGs obtained

resultsEight ICGs, including CTLA4, ICOS, TNFRSF4, CD27, B- and T-lymphocyte attenuator (BTLA), ADORA2A, CD40LG, and CD28, were found to be positively correlated with CD274. Among the eight ICGs, seven ICGs (CTLA4, ICOS, TNFRSF4, CD27, BTLA, CD40LG, and CD28) were significantly negatively correlated with TMB. The majority of the adaptive immune resistance pathway genes were positively correlated with ICGs positively correlated with CD274. The survival analysis utilizing the TCGA-OSCC data showed that, although CD274 was not significantly associated with overall survival (OS), the majority of ICGs positively correlated with CD274 (BTLA, CD27, CTLA4, CD40LG, CD28, ICOS, and TNFRSF4) were significantly correlated with OS, whereby their low-expression predicted a favorable prognosis. The survival analysis based on the gene pair subtypes showed that the combination subtypes of CD274_low/BTLA_low, CD274_low/CD27_low, CD274_low/CTLA4_low, CD8A_high/BTLA_low, CD8A_high/CD27_low, and CD8A_high/CTLA4_low predicted favorable OS.

conclusionThe results in this study provide a theoretical basis for prognostic immune subtyping of OSCC and highlight the importance of developing future immunotherapeutic strategies for treating oral cancer.

Indexed as

immune checkpoint genesimmune subtypesoral and squamous cell carcinomaPDL1prognosis

Identifiers

PMID35127742
PMCPMC8810827
OpenAlexW4205867807

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.