Evidence map›Paper›PMID 35127739›Full record

ArticleFrontiers in medicine2021

Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle.

Kinga Borsodi, Helga Balla, Péter József Molnár, Ádám Lénárt, István Kenessey, András Horváth, Attila Keszthelyi, Miklós Romics, Attila Majoros, Péter Nyirády and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Editorial: Kinin 2022 Meeting, Annecy, France.Journal of clinical medicine · 2023
    Article
  7. Dog and human bladders have different neurogenic and nicotinic responses in inner versus outer detrusor muscle layers.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  8. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Kinga BorsodiInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Helga BallaInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Péter József MolnárInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Ádám LénártInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
István Kenessey2ndDepartment of Pathology, Semmelweis University, Budapest, Hungary.
András HorváthDepartment of Urology, Semmelweis University, Budapest, Hungary.
Attila KeszthelyiDepartment of Urology, Semmelweis University, Budapest, Hungary.
Miklós RomicsDepartment of Urology, Semmelweis University, Budapest, Hungary.
Attila MajorosDepartment of Urology, Semmelweis University, Budapest, Hungary.
Péter NyirádyDepartment of Urology, Semmelweis University, Budapest, Hungary.
Stefan OffermannsDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Zoltán BenyóInstitute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Semmelweis University · HUMax Planck Institute for Heart and Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in the pathophysiology of detrusor overactivity. The present study aims to elucidate the signaling pathways of BK-induced detrusor muscle contraction, with the goal of better understanding the molecular regulation of micturition and identifying potential novel therapeutic targets of its disorders. Experiments have been carried out on bladders isolated from wild-type or genetically modified [smooth muscle-specific knockout (KO): Gα

Indexed as

bradykinindetrusor reactivityRho-kinasesignal transductionurinary bladder smooth muscle

Identifiers

PMID35127739
PMCPMC8811450
OpenAlexW4205974544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.