Evidence map›Paper›PMID 35127720›Full record

ArticleFrontiers in cell and developmental biology2021

RNAi Screen of RING/U-Box Domain Ubiquitin Ligases Identifies Critical Regulators of Tissue Regeneration in Planarians.

John M Allen, Madison Balagtas, Elizabeth Barajas, Carolina Cano Macip, Sarai Alvarez Zepeda, Ionit Iberkleid, Elizabeth M Duncan, Ricardo M Zayas

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. eLife · 2025
    Article
  2. bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

John M AllenDepartment of Biology, San Diego State University, San Diego, CA, United States.
Madison BalagtasDepartment of Biology, San Diego State University, San Diego, CA, United States.
Elizabeth BarajasDepartment of Biology, San Diego State University, San Diego, CA, United States.
Carolina Cano MacipDepartment of Biology, San Diego State University, San Diego, CA, United States.
Sarai Alvarez ZepedaDepartment of Biology, San Diego State University, San Diego, CA, United States.
Ionit IberkleidDepartment of Biology, San Diego State University, San Diego, CA, United States.
Elizabeth M DuncanDeparment of Biology, University of Kentucky, Lexington, KY, United States.
Ricardo M ZayasDepartment of Biology, San Diego State University, San Diego, CA, United States.
San Diego State University · USUniversity of Kentucky · US

Funding

The role of muscle contraction in gene activation and tissue regenerationR35GM142679 · NIGMS · UNIVERSITY OF KENTUCKY · PI DUNCAN, ELIZABETH MARIE · 2021 to 2025
$2.0M
Molecular mechanisms underlying sensory neuron regeneration and functionR01GM135657 · NIGMS · SAN DIEGO STATE UNIVERSITY · PI ZAYAS, RICARDO M. · 2020 to 2023
$1.8M
NIGMS NIH HHS R01 GM135657NIGMS NIH HHS R35 GM142679
6 · The paper itself

Abstract

Regenerative processes depend on the interpretation of signals to coordinate cell behaviors. The role of ubiquitin-mediated signaling is known to be important in many cellular and biological contexts, but its role in regeneration is not well understood. To investigate how ubiquitylation impacts tissue regeneration

Indexed as

E3 ubiquitin ligasesplanarianPRC1Prpf19regenerationRNF2stem cells

Identifiers

PMID35127720
PMCPMC8807557
OpenAlexW4205281344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.