Evidence map›Paper›PMID 35127591›Full record

ArticleFrontiers in pediatrics2021

Low Vitamin D Levels at Birth and Early Respiratory Outcome in Infants With Gestational Age Less Than 29 Weeks.

Honoré Papalia, Anais Samonini, Christophe Buffat, E Gras, Clotilde des Robert, Jean-Francois Landrier, Vanessa Pauly, Farid Boubred

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Honoré PapaliaNeonatal Unit, Hospital University La Conception, APHM, Marseille, France.
Anais SamoniniNeonatal Unit, Hospital University La Conception, APHM, Marseille, France.
Christophe BuffatLaboratory of Biochemistry and Molecular Biology, Hospital University la Conception, APHM, Marseille, France.
E GrasNeonatal Unit, Hospital University La Conception, APHM, Marseille, France.
Clotilde des RobertNeonatal Unit, Hospital University La Conception, APHM, Marseille, France.
Jean-Francois LandrierAix-Marseille University, INSERM, INRAE, C2VN, Marseille, France.
Vanessa PaulyEA 3279, CEReSS-Health Service Research and Quality of Life Center, Public Health and Medical Information Department, APHM, Marseille, France.
Farid BoubredNeonatal Unit, Hospital University La Conception, APHM, Marseille, France.
Assistance Publique Hôpitaux de Marseille · FRInserm · FRCeres · USHôpital de la Conception · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D (VitD) is involved in lung development but its influence on respiratory distress syndrome of extremely preterm (EPT) infants have been little investigated. In this study, we examined the influence of low vitamin D status at birth on early respiratory outcomes of this vulnerable infant population.

methodsCord blood 25(OH)D levels ≤ 75 nmol/L were considered as Low vitamin D levels. Stepwise logistic regression and classification regression-tree analyses were used and the primary outcome was the combined outcome of death or mechanical ventilation need by the end of the first week (death or MV DoL7) as a marker od RDS severity.

resultsThe mean (SD) GA and birth weight were 26 (1.4) weeks and 801 (212) gr, respectively; 81/109 (74%) infants had low 25(OH)D levels. Infants with low VitD levels had 25% higher initial FiO

conclusionLow vitamin D levels at birth are associated with early adverse respiratory outcomes in infants with GA less 29 weeks. Further largest studies are needed to confirm this association.

Indexed as

bronchopulmonary dysplasiaextremely preterm infantsLISA (less invasive surfactant administration)nasal CPAP (continuous positive airway pressure)RDS—respiratory distress syndromeSGA (samll for gestational age)surfactantvitamin D

Identifiers

PMID35127591
PMCPMC8814585
OpenAlexW4206897548

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.