Evidence map›Paper›PMID 35127558›Full record

ArticleFrontiers in cellular and infection microbiology2021

Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice.

Hobby Aggarwal, Priya Pathak, Vishal Singh, Yashwant Kumar, Manoharan Shankar, Bhabatosh Das, Kumaravelu Jagavelu, Madhu Dikshit

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Polyprenylated Acylphloroglucinols fromPharmaceuticals (Basel, Switzerland) · 2025
    Article
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  8. Article
  9. Review
  10. Bile acids and microbes in metabolic disease.World journal of gastroenterology · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Hobby AggarwalPharmacology Division, Council of Scientific and Industrial Research (CSIR)-Central Drug Research Institute, Lucknow, India.
Priya PathakPharmacology Division, Council of Scientific and Industrial Research (CSIR)-Central Drug Research Institute, Lucknow, India.
Vishal SinghDepartment of Nutritional Sciences, The Pennsylvania State University, State College, PA, United States.
Yashwant KumarNon-Communicable Diseases Division, Translational Health Science and Technology Institute, Faridabad, India.
Manoharan ShankarMicrobial Physiology Laboratory, Department of Bioscience & Bioengineering, Indian Institute of Technology, Jodhpur, India.
Bhabatosh DasMolecular Genetics Laboratory, Infection and Immunology Division, Translational Health Science and Technology Institute, Faridabad, India.
Kumaravelu JagaveluPharmacology Division, Council of Scientific and Industrial Research (CSIR)-Central Drug Research Institute, Lucknow, India.
Madhu DikshitPharmacology Division, Council of Scientific and Industrial Research (CSIR)-Central Drug Research Institute, Lucknow, India.
Central Drug Research Institute · INTranslational Health Science and Technology Institute · INIndian Institute of Technology Jodhpur · INPennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of oxidative and nitrosative stress has been implied in both physiology and pathophysiology of metabolic disorders. Inducible nitric oxide synthase (iNOS) has emerged as a crucial regulator of host metabolism and gut microbiota activity. The present study examines the role of the gut microbiome in determining host metabolic functions in the absence of iNOS. Insulin-resistant and dyslipidemic iNOS

Indexed as

Insulin ResistanceAnimalsGram-Positive BacteriaMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IIVancomycinNitric Oxide Synthase Type IIVancomycindyslipidemiagut microbiotaiNOS−/− miceinsulin resistancemetabolome analysisobesity

Identifiers

PMID35127558
PMCPMC8807491
OpenAlexW4205170790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.